On March 26, 2025 Zai Lab Limited (NASDAQ: ZLAB; HKEX: 9688) reported that data from preclinical studies of the Company’s internally discovered and developed next-generation, investigational oncology therapies, ZL-6201, an LRRC15 antibody-drug conjugate (ADC) for the treatment of sarcoma, and ZL-1222, a PD-1 targeted IL-12 immunocytokine for cancer immunotherapy, will be presented during poster sessions at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2025 taking place April 25-30, 2025 in Chicago, Illinois (Press release, Zai Laboratory, MAR 26, 2025, View Source [SID1234651495]).

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"Aligned with our strategy for our internally developed global oncology pipeline, ZL-6201 and ZL-1222 are promising investigational compounds with the potential to address multiple cancer types, including several that remain challenging to treat with current standard-of-care therapies," said Rafael G. Amado, M.D., President, Head of Global Research and Development at Zai Lab.

LRRC15 is a type I transmembrane protein and an appealing target for cancer therapy because it is overexpressed in various mesenchymal tumors, such as sarcoma, glioblastoma and melanoma. Zai Lab is evaluating ZL-6201 as a potential first-in-class LRRC15 ADC targeting multiple solid tumors.

Interleukin-12 treatments have demonstrated potential to offer therapeutic benefit across a range of cancer types; however, narrow therapeutic windows and toxicity concerns have limited the benefit of this therapeutic class. Zai Lab is evaluating ZL-1222 as a potential next-generation PD-1-targeted IL-12 immunocytokine for cancer immunotherapy across a variety of indications, potentially combining potent antitumor activity with improved systemic safety.

Details regarding the Zai Lab poster presentations at AACR (Free AACR Whitepaper) 2025 are as follows:

Title: Discovery and characterization of a novel LRRC15-targeting antibody-drug conjugate (ADC) for the treatment of solid tumors
Presenter: Bing Wan, Ph.D., Executive Director, Biology, Zai Lab
Session Title: New and Emerging Cancer Drug Targets
Date/Time: Tuesday, April 29, 2025, from 9:00 a.m. – 12:00 p.m. CT
Location: McCormick Place Convention Center, Poster Section 17
Poster Board Number: 23
Published Abstract Number: 4266

Title: Cis-delivery of a potency-reduced IL-12 via an anti-PD-1 single-chain antibody exhibits potent anti-tumor activity
Presenter: Linda Liu, Ph.D., Senior Vice President, Biologics Discovery, Zai Lab
Session Title: Late-Breaking Research: Clinical Research 1
Date/Time: Monday, April 28, 2025, from 2:00 p.m. – 5:00 p.m. CT
Location: McCormick Place Convention Center, Poster Section 53
Poster Board Number: 1
Publish Abstract Number: LB2024