On July 14, 2020 Y-mAbs Therapeutics, Inc. (the "Company" or "Y-mAbs") (Nasdaq: YMAB) a late-stage clinical biopharmaceutical company focused on the development and commercialization of novel, antibody-based therapeutic products for the treatment of cancer, reported that Brian H. Santich, PhD, from Memorial Sloan Kettering ("MSK") will present an update on the Company’s SADA technology platform at the Society of Nuclear Medicine and Molecular Imaging ("SNMMI") Virtual Annual Meeting on July 14, 2020 (Press release, Y-mAbs Therapeutics, JUL 14, 2020, View Source [SID1234561861]). The SADA technology was licensed by the Company from MSK and Massachusetts Institute of Technology ("MIT") earlier this year.
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Dr. Santich will present how the SADA technology’s 2-step payload delivery can be achieved in an in-vitro setting, where tumors were shown to shrink or completely disappear, while other tissues were spared. No clearing agent was needed, and no significant toxicity to bone marrow, kidneys or liver tissues was observed. We believe that the SADA technology may allow for rapid clearance of the compound, while maintaining high target uptake, and thereby causing less immunogenicity. In addition, the SADA technology appears to be modular, whereby any DOTA-modified radioactive payload combined with any therapeutic antibody seems possible.
"We are excited about the prospects of SADA technology, and this far we have four SADA targets in pre-clinical development. This includes our new construct, B7-H3 SADA, which we intend to use for the treatment of prostate cancer," stated Thomas Gad, Founder, Chairman and President.
Dr. Claus Moller, Chief Executive Officer, continued, "We look forward to further advancing the SADA technology, and plan to submit the first IND for a SADA construct in 2021. We have high hopes to see Liquid RadiationTM transform today’s cancer treatments."
Researchers at MSK including Dr. Santich, developed the SADA technology for radioimmunotherapy, which is exclusively licensed by MSK to Y-mAbs. Dr. Santich has intellectual property rights and interests in the technology, and as a result of this licensing arrangement, MSK has institutional financial interests in the technology and Y-mAbs.