On April 8, 2022 Y-mAbs Therapeutics, Inc. (the "Company" or "Y-mAbs") (Nasdaq: YMAB) a commercial-stage biopharmaceutical company focused on the development and commercialization of novel, antibody-based therapeutic products for the treatment of cancer, reported that a poster presentation featuring preclinical data from its GD2 SADA construct will be presented at the AACR (Free AACR Whitepaper) Annual Meeting 2022, which takes place in New Orleans, Louisiana from April 8-13, 2022 (Press release, Y-mAbs Therapeutics, APR 8, 2022, View Source [SID1234611719]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Pre-clinical models have shown that the tetramerizing function of the SADA domain appears to be important to the binding activity and anti-tumor effect of GD2 SADA. Data confirms that the SADA domain seems to increase tumor antigen binding, uptake and persistence in tumor tissue, and markedly improves anti-tumor responses in pre-clinical models.

The SADA technology was licensed by the Company from Memorial Sloan Kettering ("MSK") and the Massachusetts Institute of Technology. Researchers at MSK developed the SADA technology for radioimmunotherapy, which is exclusively licensed by MSK to Y-mAbs. MSK has institutional financial interests in the technology.