On August 19, 2022 Verismo Therapeutics, a Penn-spinout and the company behind the novel KIR-CAR platform technology for CAR T-cell therapy, reported that it has submitted an Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) requesting approval to initiate its first-in-human Phase 1 clinical trial of SynKIR-110 in patients with mesothelin-expressing ovarian cancer, mesothelioma and cholangiocarcinoma (Press release, Verismo Therapeutics, AUG 19, 2022, View Source [SID1234618517]).

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Pending regulatory approval, the company plans to initiate the STAR-101 (SynKIR T cell Advanced Research) trial in Q1 2023. This trial will mark the first-in-human study of the KIR-CAR platform technology, which harnesses the power of natural killer (NK) cells in genetically re-engineered CAR T-cells and aims to shift the paradigm of treatment of solid tumors.

"Initiation of the STAR-101 clinical trial based on the KIR-CAR platform technology is a momentous company milestone that represents years of research from industry pioneers and the tremendous focus and commitments of the Verismo team," said Dr. Bryan Kim, CEO of Verismo. "We are thrilled to advance our treatment one step closer to helping patient populations with severely unmet medical needs."