On August 16, 2023 Vergent Bioscience, a clinical-stage biotechnology company developing tumor-targeted imaging agents, and its wholly owned subsidiary Vergent Bioscience Australia Pty Ltd, reported that new clinical data from a Phase 2 study of the company’s investigational agent VGT-309 will be presented at the 2023 World Conference on Lung Cancer (#WCLC23) hosted by the International Association for the Study of Lung Cancer (IASLC), taking place September 9-12, 2023, in Singapore (Press release, Vergent Bioscience, AUG 16, 2023, View Source [SID1234634459]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
"We’ve steadily advanced the VGT-309 clinical program and look forward to sharing the latest results from our Phase 2 study evaluating the safety, efficacy, and dosing of this novel compound," said John Santini, Ph.D., president and chief executive officer at Vergent Bioscience. "VGT-309 has the potential to fill deficits in tumor visualization during surgery to optimize outcomes for patients."
Early Phase 1 and 2 clinical trials evaluating VGT-309 in lung cancer yielded compelling safety and efficacy data that support the agent’s ability to help surgeons see difficult-to-find or previously undetected tumors in real-time, ensuring all tumor tissue is removed during minimally invasive (MIS) and robotic-assisted surgical procedures.
Following are details about the VGT-309 presentation at the 2023 WCLC:
Title: Results from a Phase II trial of a Tumor-Activated Fluorescent Molecule for the Intra-Operative Identification of Lung Cancer
Presenter: Professor Gavin M. Wright, Ph.D., director of Surgical Oncology, St. Vincent’s Hospital, Melbourne, Australia
Abstract/Session: #844; MA11.06 – New Technology and Innovations in Early-Stage Lung Cancer
Date/Time: 2:30 – 3:30 PM Singapore/2:30 – 3:30 AM ET, September 11, 2023
Location: Suntec Singapore Convention & Exhibition Centre, Room 405C
About VGT-309
VGT-309 is a tumor-targeted imaging agent designed to enable a complete solution for optimal tumor visualization during open, MIS, and robotic-assisted surgical procedures. VGT-309 is delivered to patients via a short infusion several hours before surgery. Invented in Professor Matt Bogyo’s Lab at Stanford University School of Medicine, the molecule binds tightly (i.e., covalently) to cathepsins, a family of proteases that are overexpressed across a broad range of solid tumors. This approach provides distinct clinical advantages and positions VGT-309 as an ideal tumor imaging agent. VGT-309’s imaging component is the near infrared (NIR) dye indocyanine green (ICG), which is compatible with all commercially available NIR intraoperative imaging systems that support MIS technologies and is the preferred dye to minimize confounding background autofluorescence.