On January 28, 2021 Universal Diagnostics (UDX), an in-vitro diagnostics company developing minimally-invasive, blood-based solutions for detecting cancer early, reported promising new data for its investigational blood-based lung cancer test (Press release, Universal Diagnostics, JAN 28, 2021, View Source [SID1234574384]). The data, presented at the IASLC 2020 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer (#WCLC20), held virtually 28th-31st January 2021, used methylation status measurement of the tumour-derived portion from cell-free DNA (cfDNA) in plasma for patient classification. Results of the study show the potential of the test to detect different lung cancer sub-types early, with high sensitivity and specificity, and indicate the potential of using blood-based screening for wider population regardless of the smoking-status of the patient.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Cell-Free DNA (cfDNA) Methylation Assay Allows for Early Detection and Identification of Lung Cancer"

Tweet this
"These initial results from our lung cancer test study are promising, particularly for detecting cancer at the early stages. With current methods for lung cancer screening being limited, with the majority of patients being detected too late, we believe there is a significant opportunity to improve outcomes for lung cancer patients using a simple and accurate blood-based test for early detection through mass screening," said Juan Martínez-Barea, Co-Founder and President of Universal Diagnostics. "We will now build on these preliminary results and plan to move forward with test development, including starting clinical sample collection studies and further improving the panel and its performance. Beyond this, the results demonstrate our ability to leverage our technology for other cancer tests. "

In the study (P46.06 – "Cell-Free DNA (cfDNA) Methylation Assay Allows for Early Detection and Identification of Lung Cancer"), plasma samples of 37 lung cancer patients and 71 asymptomatic age, gender and smoking-history matching controls were assessed using UDX’s 10 methylation marker panel. The panel exhibited good lung cancer detection potential, with sensitivity for detecting lung cancer of 73% (27/37) at 90% (64/71) specificity. A total of 82% of adenocarcinoma (9/11), 80% of squamous cell carcinoma (8/10), 73% of small cell lung cancer (8/11) and 40% of other rare lung cancer subtypes (2/5) were correctly identified. Notably, the sensitivity for stage I cancers was 73% (11/15).