On February 10, 2022 Ucello Therapeutics ("Ucello"), a biotechnology company developing universal CAR-T therapies, reported the successful completion of a US$25 million Series A financing (Press release, Ucello Therapeutics, FEB 10, 2022, View Source [SID1234609738]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The funding round was led by Matrix Partners China, along with other investors Co-Win Ventures, Northern Light Venture Capital, and Elikon Venture. Also joining the round was existing angle investor Chengdu Bio-town Fund.

Proceeds from the financing will be used to advance the company’s development of proprietary universal CAR-T technology platform CBT-X20, progress pipeline programs including lead asset AT19 through to US and China IND filings, and build a state of the art GMP-ready clinical manufacturing facilities.

"We are delighted to have achieved this significant milestone, which allows us to welcome several top caliber investors such as Matrix Partners China, Co-Win Ventures, Northern Light Venture Capital, Elikon Venture, and Chengdu Bio-town Fund," said Dr. Qiang Zou, Chairman and CEO of Ucello. "With this funding, we will further accelerate our goal of developing breakthrough universal CAR-T therapies and move our pipeline towards clinical development where we hope to help patients worldwide as soon as possible."

"Cell therapy is a fast-moving field and the next generation of therapies could be off-the-shelf in nature," said Matrix Partners China partner Dr. Eric Yu. "Allogeneic cell therapy, like the universal CAR-T that Ucello is developing, could potentially address huge unmet medical needs by making cell therapy a lot more accessible and readily available. Ucello’s universal CAR-T cell therapy platform has demonstrated great potential through excellent early clinical results in investigator-initiated trials with global leading safety and efficacy profiles. We believe the company is well-positioned to bring benefits to patients in China and globally as early as possible."

"Ucello’s products at this stage have demonstrated unparalleled advantages for patients who have previously received bone marrow transplants, as well as for those whose conditions continue to progress after autologous CAR-T treatment. It is not only cost-controlled, but also truly meets the clinical need for timeliness," said Dr. Xin Huang, Managing Partner of the Co-Win Ventures. "This obvious advantage in performance is mainly thanks to the team’s commitment to benefits for patients alongside years of research and deep knowledge in the field of cord blood-derived CAR-T cell technology. We are pleased to have the opportunity to help Ucello build on its success and accelerate the clinical application of its products to bring sustainable clinical benefits to more patients."

"Universal CAR-T is a very competitive field for players in the cell therapy sector, in which few breakthroughs having been made so far due to many technical hurdles," stated Mr. Feng Deng, Founding and Managing Partner of the Northern Light Venture Capital. "With a deep understanding of the immunotherapy and years of continuous efforts, the Ucello team has developed a unique platform technology which started to produce excellent clinical outcome with great potential to develop future blockbusters. We are very pleased to continually support the development of Ucello."

Dr. Jianfeng Zhou, Director of the Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, said

"Universal CAR-T cell therapy is the current focus and hotspot of clinical research in the field of hematological oncology worldwide. We expect Ucello to achieve breakthroughs in this highly challenging field in both China and globally."