On October 30, 2024 Triumvira Immunologics, a clinical-stage company developing novel, targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors, reported that Dr. Ecaterina E. Dumbrava, Assistant Professor in the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center, will present a late-breaking abstract at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 2024, being held from November 6-10, 2024, in Houston, Texas (Press release, Triumvira Immunologics, OCT 30, 2024, View Source [SID1234647552]).
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The oral presentation will highlight interim data from Triumvira’s ongoing Phase 1/2 study, TACTIC-3 clinical trial, which is investigating the safety and efficacy of TAC101-CLDN18.2, a novel T cell therapy targeting Claudin 18.2+ advanced solid tumors. The therapy leverages Triumvira’s proprietary T cell Antigen Coupler (TAC) technology, a unique platform that activates natural T cell functions to combat solid tumors effectively and safely.
"We are excited to share promising initial results from our TACTIC-3 trial at SITC (Free SITC Whitepaper) 2024," said Robert Williamson, President of Triumvira Immunologics. "Our approach harnesses the body’s natural immune system to target challenging cancers like Claudin 18.2+ solid tumors. This represents a significant advancement in our mission to develop next-generation cell therapies that could transform the treatment landscape for patients with difficult-to-treat cancers."
Details of the abstract presentation are as follows:
Abstract Number: 1472
Abstract Title: A phase 1/2 study evaluating the safety and efficacy of autologous TAC T cells in subjects with claudin 18.2+ advanced solid tumors
Authors: Ecaterina E. Dumbrava, Syma Iqbal, Simon Turcotte, Gregory Botta, Benjamin Schlechter, Geoffrey Ku, Peter Hosein, Sam Saibil, Miriam Gavriliuc, Maria Apostolopoulou, Mobolaji Giwa, Kara Moss, Swaminathan Murugappan, Davendra Sohal
Session: Biotech Breakthroughs – Solid Tumor IO at the Tipping Point
Date: Friday, November 8, 2024, between 1:45 p.m. and 3:20 p.m. CDT
About TACTIC-3
The TACTIC-3 trial (NCT05862324) is a first-in-human Phase 1/2 study designed to evaluate the safety, recommended Phase II dose (RP2D), pharmacokinetics, and efficacy of TAC101-CLDN18.2 in patients with Claudin 18.2+ solid tumors who have undergone 2 or more lines of prior therapy (1 prior line in patients with pancreatic tumors). The trial includes subjects with advanced gastric and other solid tumors expressing Claudin 18.2, with the potential to address significant unmet medical needs in oncology.