On May 26, 2023 Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, reported two poster presentations at the 2023 American Association of Clinical Oncology (ASCO) (Free ASCO Whitepaper) annual meeting to be held in Chicago, IL (June 2-6) (Press release, Transgene, MAY 26, 2023, View Source [SID1234632163]).
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The posters will highlight that in challenging clinical settings:
✓ TG4001 induced T-cell responses against HPV16 antigens in the ongoing Phase II trial.
✓ TG4050: 100% of the patients treated with the individualized therapeutic cancer vaccine developed multiple functional T cell responses against targeted neoantigens, which may be associated with an improved outcome in patients with head and neck cancer in the adjuvant setting.
Details for the presentations are as follows:
TG4001
Abstract Title: Immunogenicity and clinical activity of tipapkinogen sovacivec (TG4001), an HPV-16 cancer vaccine: A randomized phase 2 study in advanced anogenital cancers.
Abstract Number: 2630
Session Title: Developmental Therapeutics—Immunotherapy
Session Date and Time: Saturday, June 3, 2023, 8:00 AM-11:00 AM (CDT)
Link to the abstract: click here
TG4050
Abstract Title: Safety and immunogenicity of TG4050: A personalized cancer vaccine in head and neck carcinoma.
Abstract Number: 6082
Session Title: Head and Neck Cancer
Session Date and Time: Monday, June 5, 2023, 1:15 PM-4:15 PM (CDT)
Link to the abstract: click here
The abstracts are available on Transgene’s website.
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About TG4001
TG4001 is an investigational therapeutic vaccine based on a non-propagative, highly attenuated Vaccinia vector (MVA), which is engineered to express HPV16 antigens (E6 & E7) and an adjuvant (IL-2). TG4001 is designed to have a two-pronged antiviral approach: to alert the immune system specifically to cells presenting the HPV16 E6 and E7 antigens, that can be found in HPV16-related tumors, and to further stimulate the infection-clearing activity of the immune system through interleukin 2 (IL-2). TG4001 has been administered to more than 350 individuals, demonstrating good safety and promising efficacy results [1]. Its mechanism of action and good safety profile make TG4001 an excellent candidate for combinations with other therapies in HPV-mediated solid tumors.
It is currently evaluated in a multi-center, open label, randomized Phase II trial (NCT03260023) designed to compare the efficacy of the combination of TG4001 and avelumab versus avelumab alone in patients with advanced, recurrent and/or metastatic HPV16-positive anogenital cancers who have disease progression after a maximum of one line of systemic treatment, or who are not eligible for first-line chemotherapy.
About TG4050
TG4050 is an individualized immunotherapy being developed for solid tumors that is based on Transgene’s myvac technology and powered by NEC’s longstanding artificial intelligence (AI) expertise. This virus-based therapeutic vaccine encodes neoantigens (patient-specific mutations) identified and selected by NEC’s Neoantigen Prediction System. The prediction system is based on more than two decades of expertise in AI and has been trained on proprietary data allowing it to accurately prioritize and select the most immunogenic sequences.
TG4050 is designed to stimulate the immune system of patients in order to induce a T-cell response that is able to recognize and destroy tumor cells based on their own neoantigens. This individualized immunotherapy is developed and produced for each patient.
TG4050 is being evaluated in two Phase I clinical trials for patients with HPV-negative head and neck cancers (NCT04183166) and ovarian cancer (NCT03839524), and has shown promising initial results.