Transgene to Present a Poster on Updated Data for TG4050 at SITC 2024

On October 7, 2024 Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, reported that it will present a poster highlighting median 24-month follow up from the ongoing randomized Phase I trial of its individualized therapeutic cancer vaccine, TG4050 at the 39th Society for ImmunoTherapy of Cancer (SITC) (Free SITC Whitepaper) annual meeting (Press release, Transgene, OCT 7, 2024, View Source [SID1234647066]). This presentation will emphasize efficacy and disease-free survival outcomes in patients with head and neck cancers. SITC (Free SITC Whitepaper) annual meeting will take place in Houston, Texas, USA, from November 6 to 10, 2024.

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The abstract will be available on the SITC (Free SITC Whitepaper) website on November 5, 2024, from 3 p.m. CET.

Poster details

Title: "Randomized phase I trial of adjuvant individualized TG4050 vaccine in patients with locally advanced resected HPV-negative head and neck squamous cell carcinoma (HNSCC)".

Poster and abstract number: 650
Date and Time: Thursday, November 7, 2024 at 4 p.m. CET
Author: C. Le Tourneau

TG4050 is an individualized immunotherapy being developed for solid tumors that is based on Transgene’s myvac technology and powered by NEC’s longstanding artificial intelligence (AI) expertise. TG4050 is being evaluated in a randomized multicenter Phase I/II clinical trial as a single agent in the adjuvant treatment of HPV-negative head and neck cancers (NCT04183166).

Transgene previously presented data in April 2024, that showed that all patients who received TG4050 remained disease-free after a median follow-up of 18.6 months, comparing favorably to the observational arm which saw 3 out of 16 patients relapse during the same time period.

Transgene and NEC are continuing the joint development of TG4050 in this indication with a Phase II extension of the trial, which is currently enrolling patients.