On November 1, 2017 TG Therapeutics, Inc. (NASDAQ:TGTX), reported that updated data for TGR-1202 (umbralisib), the Company’s once-daily PI3K delta inhibitor, and TG-1101 (ublituximab), the Company’s novel glycoengineered anti-CD20 monoclonal antibody, have been selected for presentation at the upcoming 59th American Society of Hematology (ASH) (Free ASH Whitepaper) annual meeting, to be held December 9-12, 2017, at the Georgia World Congress Center in Atlanta, Georgia (Press release, TG Therapeutics, NOV 1, 2017, View Source [SID1234521406]). Abstracts are now available online and can be accessed on the ASH (Free ASH Whitepaper) meeting website at www.hematology.org . Clinical abstract highlights as well as the details of clinical and preclinical posters to be presented at ASH (Free ASH Whitepaper) are outlined below.

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Clinical Abstract Highlights:

TGR-1202 Integrated Analysis: 336 patients with relapsed/refractory Lymphoid Malignancies exposed to a TGR-1202 based regimen for upwards of 4+ years, demonstrated a favorable safety profile with infrequent Grade 3/4 adverse events prevalent amongst prior generation PI3K delta inhibitors: transaminitis ( < 3%), colitis ( < 1%), and pneumonitis ( < 0.5%)
Kinase Inhibitor Intolerance Study: In patients with Chronic Lymphocytic Leukemia (CLL) who are intolerant to prior BTK or PI3K delta inhibitor therapy, no patients (n=22) discontinued due to TGR-1202 intolerance with a median follow-up of 6 months
TG-1101 + TGR-1202 + PD-1 Triplet: 60% ORR (3 of 5) observed in BTK refractory CLL patients treated with the triple combination of TGR-1202 plus TG-1101 plus pembrolizumab
Poster presentations at the ASH (Free ASH Whitepaper) 2017 meeting include the following:

Sunday December 10, 2017:

Title: Phase I/II Study of Pembrolizumab in Combination with Ublituximab (TG-1101) and Umbralisib (TGR-1202) in Patients with Relapsed/Refractory CLL
Abstract Number: 3010
Session: 642. CLL: Therapy, excluding Transplantation: Poster II
Date and Time: Sunday, December 10, 2017; 6:00 PM – 8:00 PM ET
Location: Georgia World Congress Center, Bldg A, Lvl 1, Hall A2
Presenter: Anthony R. Mato, MD, University of Pennsylvania, Philadelphia, PA

Title: Umbralisib/TGR-1202 as a Novel Dual PI3K/CK1 Inhibitor Has a Unique Therapeutic Role in Silencing Oncogenes in Aggressive Lymphomas
Abstract Number: 2809
Session: 625. Lymphoma: Pre-Clinical—Chemotherapy and Biologic Agents: Poster II
Date and Time: Sunday, December 10, 2017; 6:00 PM – 8:00 PM ET
Location: Georgia World Congress Center, Bldg A, Lvl 1, Hall A2
Presenter: Ipsita Pal, PhD, Columbia University Medical Center, New York, NY

Title: Differential Regulation of T Cells By PI3K Delta Inhibitors in a CLL Murine Model
Abstract Number: 3009
Session: 642. CLL: Therapy, excluding Transplantation: Poster II
Date and Time: Sunday, December 10, 2017; 6:00 PM – 8:00 PM ET
Location: Georgia World Congress Center, Bldg A, Lvl 1, Hall A2
Presenter: Kamira K. Maharaj, BS, Moffit Cancer Center, Tampa, FL
Monday, December 11, 2017:

Title: An Integrated Safety Analysis of the Next Generation PI3Kδ Inhibitor Umbralisib (TGR-1202) in Patients with Relapsed/Refractory Lymphoid Malignancies
Abstract Number: 4037
Session: 623. Mantle Cell, Follicular, and Other Indolent B-Cell Lymphoma—Clinical Studies: Poster III
Date and Time: Monday, December 11, 2017; 6:00 PM – 8:00 PM ET
Location: Georgia World Congress Center, Bldg A, Lvl 1, Hall A2
Presenter: Matthew S. Davids, MD, Dana Farber Cancer Institute, Boston, MA

Title: KI Intolerance Study: A Phase 2 Study to Assess the Safety and Efficacy of Umbralisib (TGR-1202) in Patients with Chronic Lymphocytic Leukemia (CLL) Who Are Intolerant to Prior BTK or PI3K-δ Inhibitor Therapy
Abstract Number: 4314
Session: 642. CLL: Therapy, excluding Transplantation: Poster III
Date and Time: Monday, December 11, 2017; 6:00 PM – 8:00 PM ET
Location: Georgia World Congress Center, Bldg A, Lvl 1, Hall A2
Presenter: Anthony R. Mato, MD, University of Pennsylvania, Philadelphia, PA

Title: PI3K-Delta Inhibitors Induce Primary Monocyte Cytotoxicity but Do Not Alter Monocyte Differentiation
Abstract Number: 4284
Session: 641. CLL: Biology and Pathophysiology, excluding Therapy: Poster III
Date and Time: Monday, December 11, 2017; 6:00 PM – 8:00 PM ET
Location: Georgia World Congress Center, Bldg A, Lvl 1, Hall A2
Presenter: Daphne Friedman, MD, Durham VA-Duke University Medical Center, Durham, NC
The above referenced abstracts can be viewed online through the ASH (Free ASH Whitepaper) meeting website at www.hematology.org. Following each presentation, the data presented will be available on the Publications page of the Company’s website at www.tgtherapeutics.com.

TG THERAPEUTICS INVESTOR & ANALYST EVENT

TG Therapeutics will also host a reception on Sunday, December 10, 2017 beginning at 8:00pm ET with featured presentations beginning promptly at 8:15pm ET. The event will take place at the Ritz Carlton Atlanta (Downtown) in the Congress Room. This event will be webcast live and will be available on the Events page, located within the Investors & Media section of the Company’s website at www.tgtherapeutics.com, as well as archived for future review. This event will also be broadcast via conference call. To access the conference line, please call 1-877-407-8029 (U.S.), 1-201-689-8029 (outside the U.S.), and reference Conference Title: TG Therapeutics December 2017 Investor & Analyst Event.