On March 29, 2016 TESARO, Inc. (Nasdaq:TSRO), an oncology-focused biopharmaceutical company, reported it has dosed the first patient in a Phase 1, dose-escalation study of its lead anti-PD-1 monoclonal antibody candidate, TSR-042 (Press release, TESARO, MAR 29, 2016, View Source [SID:1234510113]). Following identification of a dose and schedule for TSR-042, the trial is planned to expand into tumor specific cohorts. Schedule your 30 min Free 1stOncology Demo! "TSR-042 is the first antibody candidate from our immuno-oncology portfolio to enter clinical trials, and our goal is to identify a dose and schedule for TSR-042 by the end of 2016," said Mary Lynne Hedley, Ph.D., President and COO of TESARO. "We continue to believe that immuno-oncology has the potential to transform our approach to cancer therapy and we look forward to continuing to advance our immuno-oncology portfolio. We expect to submit an investigational new drug application for a second antibody candidate from our immuno-oncology portfolio, TSR-022, our anti-TIM-3 antibody candidate, during the second quarter of this year."
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About TSR-042
TSR-042 is a monoclonal antibody candidate targeting PD-1 and was developed as part of a collaboration between TESARO and AnaptysBio, Inc. This collaboration was initiated in March of 2014, and is focused on the development of monospecific antibody drug candidates targeting TIM-3 (TSR-022), LAG-3 and PD-1 and bi-specific antibody drug candidates targeting PD-1/TIM-3 and PD-1/LAG-3, in addition to a novel bispecific antibody candidate designed to target undisclosed targets.