On May 19, 2021 Teneobio, Inc., a clinical stage biotech company focused on the discovery and development of novel multi-specific biotherapeutic antibodies, reported the publication of its bispecific human heavy chain only antibody (TNB-409) with selective IL-2βγ receptor heterodimeric agonist activity in Scientific Reports (www.nature.com/articles/s41598-021-90096-8) (Press release, TeneoBio, MAY 19, 2021, View Source;utm_medium=rss&utm_campaign=teneobio-announces-tnb-409-is-a-selective-il-2-receptor-bispecific-agonist-for-the-reatment-of-solid-tumors [SID1234580247]).

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By circumventing signaling through the α chain of the IL-2 receptor, TNB-409 minimizes Treg activation and retains robust immunostimulatory activity of T and NK cells in vitro and in vivo in monkey studies. TNB-409’s extended half-life and demonstrable safety in monkeys potentially confers a better therapeutic window for the treatment of solid tumors. TNB-409 is poised to enter phase 1 clinical studies in Q2 of 2022.

Katherine Harris, VP of Discovery at Teneobio added, "TNB-409 couples the beneficial aspects of IL-2 with Fc-mediated extended half-life, while avoiding the undesirable side effects associated with binding to IL-2Rα. TNB-409 not only achieves the desired biological activity of stimulating T and NK effector cells, moreover, it validates the applicability of Teneobio’s human single domain platform of multispecifics to target other therapeutically relevant receptor signaling pathways."