On April 8, 2024 Tempus, a leader in artificial intelligence and precision medicine, reported that it will present new data along with Pfizer at the AACR (Free AACR Whitepaper) 2024 Annual Meeting (Press release, Tempus, APR 8, 2024, View Source [SID1234641912]). The abstract, titled "Analysis of HER2 prevalence by RNA expression across solid tumors," found that by correlating HER2 protein levels by IHC/ISH and ERBB2 mRNA levels by NGS in tumors of patients with locally advanced/metastatic (LA/m) breast and gastric cancer, RNA expression in several solid tumors apart from breast or gastric cancer may correspond to HER2 IHC≥1+. These findings may open up potential therapeutic routes for HER2-directed antibody-drug conjugates in several tumor types.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
In 2022, Seagen (acquired by Pfizer in December 2023) engaged Tempus to investigate cohorts of patients with HER2 RNA expression. As part of the collaboration, Tempus’ computational and real-world evidence teams helped provide insights on the prevalence of HER2 expression in select solid tumors. Pfizer is leveraging Tempus’ multimodal database to further its HEOR and Translational Science team’s research efforts.
"We’ve been fortunate enough to work alongside the Pfizer team as they expand their understanding of HER2 expression in solid tumors, which outside of breast and gastric cancers, has not been previously well described," said Ryan Fukushima, Chief Operating Officer of Tempus. "For this specific study, we were able to tap into our existing database and analyze 4,500 de-identified records to support their research."