On January 4, 2023 TAE Life Sciences (TLS), a biological-targeted radiation therapy company developing next-generation boron neutron capture therapy (BNCT), and AIVITA Biomedical, Inc. (AIVITA), a biotech company specializing in innovative stem cell applications, repoted a partnership to address an unmet need in glioblastoma treatment (Press release, TAE Life Sciences, JAN 4, 2023, View Source [SID1234625850]). Acquiring significant amounts of quality glioblastoma tissue samples has long been a barrier in developing novel cancer therapeutics, with samples often plagued by misleading signals such as dead cells, normal cells and extracellular matrix. The enriched glioblastoma tumor initiating cells (TICs) provided by AIVITA may become targets for novel boron target drugs for future BNCT treatments.
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"We are thrilled to partner with AIVITA and leverage their ability to identify, isolate and expand high-purity populations of target cell types for therapeutic and diagnostic application," said Bruce Bauer, PhD, CEO of TAE Life Sciences. "This partnership underscores the potential that TAE Life Sciences’ next generation targeted boron drugs and low-energy accelerator-based neutron source holds as a treatment for patients living with the most difficult to treat cancers."
Under the terms of the partnership, AIVITA will provide TICs isolated and expanded from glioblastoma bulk tumors in sufficient quantities as cryopreserved live cell lines to be used by TAE Life Sciences for therapeutic target identification. Among the tumor targets to be identified are cancer biomarkers and biomarkers discovered through genomic analysis that may be novel or unique to an individual patient.
"Advancements in biomarker capture and identification remain an elusive but critical step in improving cancer care," said Hans S. Keirstead, PhD, CEO of AIVITA Biomedical. "I believe this merging of our two leading-edge technologies will lead to meaningful progress in that effort."