On March 7, 2024 Synthekine Inc., an engineered cytokine therapeutics company, reported that data from a Phase 1a/1b clinical trial of its α/β biased IL-2 partial agonist, STK-012, will be presented at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2024 taking place in San Diego, from April 5-10, 2024 (Press release, Synthekine, MAR 7, 2024, View Source [SID1234640950]). The company will also present new preclinical data for its orthogonal IL-2 (orthoIL-2) technology for cytokine-inducible cell therapies, currently being investigated in a Phase 1 study with the STK-009 + SYNCAR-001 combination therapy.
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"AACR marks the first time Synthekine will present clinical data from the ongoing trial of STK-012, our lead program and a novel approach to biasing IL-2," said Debanjan Ray, chief executive officer of Synthekine. "We are also excited to share new preclinical data with our orthoIL-2 technology comparing it head-to-head with other armoring approaches for CAR T-cell therapies. We look forward to sharing these results with the scientific community, while continuing our rapid progress to advance our broad pipeline of cytokine programs, including cytokine-inducible cell therapies, for the treatment of cancer, inflammatory and autoimmune diseases."
Details are as follows and available on the AACR (Free AACR Whitepaper) online itinerary planner:
Title: Initial results from a Phase 1a/1b study of STK-012, a first-in-class α/β IL-2 receptor biased partial agonist in advanced solid tumors (NCT05098132)
Session Title: First-in-Human Phase I Clinical Trials 2
Session Date & Time: Tuesday, Apr 9, 2024, 9:00 AM – 12:30 PM PT
Location: Poster Section 48
Poster Board Number: 11
Abstract Number: CT183
Title: Orthogonal IL-2/IL-2Rβ signaling selectively enhances and sustains a synthetic effector state via a novel mechanism and outperforms constitutive armoring approaches
Session Title: Adoptive Cellular Therapy 2
Session Date & Time: Tuesday, Apr 9, 2024, 1:30 PM – 5:00 PM PT
Location: Poster Section 40
Poster Board Number: 3
Abstract Number: 6312
Copies of the posters will be available on Synthekine’s website following presentation at the meeting.