On March 4, 2020 Sutro Biopharma, Inc. (NASDAQ: STRO), a clinical-stage drug discovery, development and manufacturing company focused on the application of precise protein engineering and rational design to create next-generation oncology therapeutics, reported proof of concept data for a next generation dual conjugated combination immunostimulatory antibody drug conjugate (IADC) (Press release, Sutro Biopharma, MAR 4, 2020, View Source [SID1234555165]). This breakthrough concept of a tumor targeting monotherapy, which simultaneously attacks tumor cells while stimulating a patient’s own immune system, has the promise of generating long-term immunity.
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The IADC was generated with Sutro’s proprietary and integrated cell-free protein synthesis platform XpressCF and site-specific conjugation platform XpressCF+. It enables precise tumor targeting with a combination of a novel toll-like receptor (TLR) agonist and a traditional antibody drug conjugate warhead.
"This is a next-generation approach that utilizes Sutro’s technology to take ADCs into the future, potentially enabling a sustained and adaptive anti-tumor immune response," said Sutro’s Chief Scientific Officer, Trevor Hallam, PhD. "Here we have showcased how a targeted cytotoxin can stimulate immunogenic cell death and provide a synergistic stimulation of immune system memory responses when paired together with TLR agonists. Generating adaptive and protective immunity from the patient’s own tumors in situ, especially in an off-the-shelf product, is a significant leap forward in targeted oncology therapeutics."
Dr. Hallam is a featured speaker at the 10th Annual World ADC London and delivering a plenary presentation titled "Targeted Immunostimulants; A Promising Approach to In Situ Immunisation." The slides will be accessible through the Clinical/Scientific Presentation and Publication Highlights page of the News section of the company’s website at www.sutrobio.com.