Sporos BioDiscovery to Present Preclinical Findings on SPR1, a Next-Generation TEAD Inhibitor, at the American Association for Cancer Research (AACR) Annual Meeting 2024

On March 6, 2024 Sporos BioDiscovery, Inc. (a portfolio company of Sporos Bioventures, LLC.), a precision oncology company developing a diversified pipeline of small molecule therapeutic programs targeting cancer vulnerabilities in the tumor and tumor microenvironment, reported that it will present two posters highlighting preclinical data from the company’s novel TEAD1 / TEAD4 isoform selective inhibitor, SPR1, at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2024, taking place April 5-10, 2024, in San Diego, CA (Press release, Sporos Bioventures, MAR 6, 2024, View Source [SID1234640892]).

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"We look forward to presenting two posters at this year’s AACR (Free AACR Whitepaper) meeting that highlight the significant preclinical work we have done to characterize SPR1 as a potential best-in-class TEAD inhibitor. In addition, our team’s expert biological analysis has uncovered a new therapeutic vulnerability that could broaden the potential use of SPR1, a TEAD1/4 inhibitor, to a new subset of cancers with certain homozygous deletions," said Stephen Rubino, Ph.D., President of Sporos BioDiscovery.

Presentation Details:

Title: TEAD1/4 inhibitors exhibit deeper biological impact and broader activity compared to TEAD1-only inhibitors in both monotherapy and combination without additional kidney toxicity
Session Category: Experimental and Molecular Therapeutics
Session Title: New Targets
Session Date and Time: Tuesday Apr 9, 2024, 1:30 p.m. – 5:00 p.m. PT
Abstract Number: 5913
Poster Number: 27

Title: VGLL4 is the target of the 3p25 homozygous deletion and presents a novel therapeutic vulnerability for TEAD1/4 but not TEAD1 inhibitors
Session Category: Experimental and Molecular Therapeutics
Session Title: YAP/TAZ/TEAD Modulators
Session Date and Time: Wednesday Apr 10, 2024, 9:00 a.m. – 12:30 p.m. PT
Abstract Number: 7266
Poster Number: 3