On February 21, 2018 Sierra Oncology, Inc. (Nasdaq: SRRA), a clinical stage drug development company focused on advancing next generation DNA Damage Response (DDR) therapeutics for the treatment of patients with cancer, reported it has been accepted to present preclinical data demonstrating that its Chk1 inhibitor, SRA737, synergizes with niraparib, a poly ADP-ribose inhibitor (PARPi), in a poster at the American Association of Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2018 being held in Chicago, Illinois from April 14-18 (Press release, Sierra Oncology, FEB 21, 2018, View Source [SID1234524082]).
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"There is a strong biological rationale for synergy between SRA737 and PARP inhibition, which is further validated by these data. Notably, this combination was effective in homologous repair proficient tumor cell lines where PARP inhibitors are substantially less active in the clinical setting," said Dr. Christian Hassig, Chief Scientific Officer of Sierra Oncology. "Sierra is designing a potential clinical study to evaluate SRA737 in combination with a PARP inhibitor, including evaluation in comparable patient populations."
Poster Title: The Chk1 inhibitor, SRA737, synergizes with niraparib to kill cancer cells via multiple cell death pathways
Session Category: Experimental and Molecular Therapeutics
Session Title: Cell Cycle, Drug Resistance, and Combinations
Session Date and Time: Monday Apr 16, 2018 8:00 AM – 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 37
Poster Board Number: 11
Permanent Abstract Number: 1853
The Poster will be available April 16, 2018 on the company’s website at www.sierraoncology.com.