Seres Therapeutics to Present Clinical Research on the Microbiome’s Impact on Allogeneic Hematopoietic Stem Cell Transplantation and Cancer Immunotherapy at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting

On May 19, 2021 Seres Therapeutics, Inc. (Nasdaq: MCRB), a leading microbiome therapeutics company, reported that it will present the latest research from its early stage clinical development programs in two presentations at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, taking place virtually from June 4-8, 2021 (Press release, Seres Therapeutics, MAY 19, 2021, View Source [SID1234580317]). In an oral presentation, Seres will share data from its collaboration with the University of Cologne (Köln, Germany) assessing the association of the microbiome on clinical outcomes in allogeneic hematopoietic stem cell transplantation (HSCT) recipients. A separate poster presentation will include data from its collaboration with Memorial Sloan Kettering Cancer Center (New York, NY) evaluating the correlation of microbiome composition with response to immune checkpoint inhibitor treatment in patients who have metastatic lung, urothelial or renal cancer, or metastatic melanoma.

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"Research has shown that disruption in the gut microbiome can affect clinical outcomes in patients treated with certain cancer treatments, including allogeneic hematopoietic stem cell transplantation and cancer immunotherapy," said Matthew Henn, Ph.D., Chief Scientific Officer at Seres. "We are looking forward to presenting data that deepens this understanding and brings further attention to the opportunity of microbiome therapeutics to modulate patient immune responses to improve outcomes as well as to reduce subsequent antibiotic resistant bacterial infections that can lead to blood stream infections during the course of various cancer treatments."

Presentation details are as follows:

Oral Abstract Presentation: Prospective longitudinal evaluation of microbiome diversity in patients with hematological malignancy undergoing allogeneic hematopoietic stem cell transplantation (HSCT), June 4, 2021, 2:30 – 5:30 pm ET, lead co-authors: Emily Walsh, Anastasia Tsakmaklis (Abstract: 7005)
Poster Presentation: Assessment of cancer-specific microbiome signature of response to immune checkpoint inhibitors, June 4, 2021, 9:00 am ET, lead co-authors: Michal Sarfaty, Christopher A. Desjardins (Abstract: 2574)