On April 29, 2021 Selecta Biosciences, Inc. (NASDAQ: SELB), a biotechnology company leveraging its clinically validated ImmTOR platform to develop tolerogenic therapies that selectively mitigate unwanted immune responses, reported three upcoming presentations at the 24th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) (Free ASGCT Whitepaper), to be held virtually from May 11-14, 2021 (Press release, Selecta Biosciences, APR 29, 2021, View Source [SID1234578764]). These presentations further demonstrate the potential of Selecta’s ImmTOR platform to mitigate AAV immunogenicity and enable redosing of gene therapy treatments for various genetic disorders.

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"We are excited to present data on ImmTOR’s potential to address current limitations in the gene therapy field including efficacy, safety and durability at ASGCT (Free ASGCT Whitepaper)," said Dr. Takashi Kei Kishimoto, Ph.D., chief scientific officer of Selecta. "The results to be presented continue to highlight ImmTOR’s ability to enable redosing of AAV-based gene therapies and prevent the production of AAV-specific neutralizing antibodies (NAbs) in vivo. As many gene therapies will be targeted to pediatric patients, maintaining therapeutic activity is of the utmost importance to families of patients with genetic disorders, a concern that we believe ImmTOR has the potential to solve moving forward."

Oral Presentation:
Presentation Title: Coadministration of AAV Expressing MDR3 (VTX-803) and ImmTOR Allows for Vector Re-Administration to Treat Progressive Familial Intrahepatic Cholestasis Type 3 (PFIC3) in Juvenile Abcb4-/- Mice
Session Title: Gene Therapy for Inborn Errors of Metabolism
Abstract Number: 29
Presenter: Nicholas D. Weber, Ph.D.
Presentation Date and Time: Tuesday, May 11, 2021 5:30 p.m. ET

An oral presentation from scientists at Vivet Therapeutics will highlight the potential of ImmTOR to enable repeated intravenous administration of liver-directed AAV vector carrying human ABCB4 cDNA (VTX-803) in a juvenile mouse model of progressive familial intrahepatic cholestasis type 3 (PFIC3). These data highlight the power of redosing AAV gene therapy with ImmTOR to sustain therapeutic efficacy in juvenile animals.
Digital Poster Presentations:
Presentation Title: ImmTOR Nanoparticles Promote Survival and Enable Repeat Gene Therapy of MMUT-Deficient Mice with Maternally-Transferred Anti-AAV Antibodies
Session Title: Metabolic, Storage, Endocrine, Liver and Gastrointestinal Diseases
Abstract Number: 483
Presenter: Petr Ilyinskii, Ph.D.
Presentation Date and Time: Tuesday, May 11, 2021 8 a.m. ET

Results presented in this poster show the potential of a combination of ImmTOR and AAV-based gene therapy vector to mitigate the detrimental impact of maternally-transferred anti-AAV antibodies in a mouse model of methylmalonic acidemia (MMA).
Presentation Title: ImmTOR Nanoparticles Enhance the Level and Durability of AAV Transgene Expression after Initial Dosing and Mitigate the Formation of Neutralizing Antibodies in Nonhuman Primates
Session Title: Immunological Aspects of Gene Therapy and Vaccines
Abstract Number: 761
Presenter: Takashi K. Kishimoto, Ph.D.
Presentation Date and Time: Tuesday, May 11, 2021 8 a.m. ET

This poster presents data from a large NHP study that builds upon previous data showing that tolerogenic ImmTOR nanoparticles can selectively mitigate anti-AAV T and B cell responses to enable vector redosing in mice and small nonhuman primates (NHP). These results indicate that ImmTOR may enhance the level and durability of transgene expression after initial treatment of AAV vector while inhibiting the formation of neutralizing antibodies.
Following the conference, the three presentations will be available in the Resources section of Selecta’s website at www.selectabio.com/resources/.