On January 27, 2025 Cambium Oncology reported that their lead drug candidate, ANT308, recently demonstrated outstanding single-agent efficacy and safety in preclinical studies (Press release, Cambium Oncology, JAN 27, 2025, View Source [SID1234649896]). The drug is mutation-agnostic, and the company observes no toxicity-limiting dosages. In addition to their Fast-Track SBIR NIH grant recently being funded for $2.4M, they have received a significant investment from OEP Innovations of Taiwan.

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ANT308 is a FIRST-IN-CLASS immunotherapeutic with broad therapeutic potential across hematologic malignancies and solid tumors with the potential to enhance response rates in cancers that are resistant to other treatments. The intellectual property portfolio is expansive and solid. We have no debt.

MULTIPLE PROOFS-OF-CONCEPT: Leukemia and Pancreatic Cancers
(1)Leukemia
ANT308 has shown strong single-agent anti-leukemia activity in 2 mouse models.
(2) Pancreatic cancer
ANT308 has shown synergistic effects with anti-PD-1 checkpoint inhibitors in 3 pancreatic cancer models.

ANT308 is a proprietary small-molecule antagonist that blocks VIP-receptor signaling on human T cells, overcoming immune suppression in the tumor microenvironment.