On April 8, 2024 SeekIn Inc., a leader in blood-based cancer early detection and monitoring technology, reported three additional validation studies that evaluate OncoSeek’s ability to detect more than nine cancer types and predict the tissue of origin with a tube of blood (Press release, SeekIn, APR 8, 2024, View Source [SID1234641895]). The data further validate the performance of OncoSeek with consistent results between the three new cohorts and the three previous cohorts of ~12,000 participants from China, the United States and Brazil. The results from three different platforms and two sample types indicate the generalization of OncoSeek’s capability for common protein marker platforms. The findings were presented at the session entitled ‘Multi-Cancer Early Detection Testing: Where Are We?’ at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting in San Diego, one of the most significant oncology conferences highlighting the work of the best minds in cancer research from institutions all over the world.
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"SeekIn has demonstrated the performance of OncoSeek at international oncology conferences before. The data we are presenting this time are based on diverse protein tumor marker (PTM) platforms and new cohorts in both retrospective and prospective settings and in symptomatic patients," said Mao Mao, MD, PhD, Founder and CEO of SeekIn. "The consistently good clinical performance enables OncoSeek to work well as a low-cost, flexible and effective cancer early detection and early diagnosis technology worldwide, especially in low- and middle-income countries."
OncoSeek was established using artificial intelligence (AI) to distinguish cancer patients from non-cancer individuals by calculating the probability of cancer (POC) index based on the quantitative results of seven PTMs and clinical information, such as gender and age. It also predicts the possible affected tissue of origin (TOO) for those who have been detected with cancer signals in blood. OncoSeek was evaluated by a large retrospective study of 9,382 participants from China and the US. The methodology and clinical effectiveness of OncoSeek were published in eClinicalMedicine with DOI View Source in July, 2023.
"Combining new with previous results, OncoSeek achieved a sensitivity of 60% with a specificity of 93%, resulting in a significantly reduced false positive rate of 7% from that of 52% according to the conventional clinical method. This enables OncoSeek to be suitably applicable to three clinical applications: (i) screening for people who have no signs or symptoms of cancer, (ii) diagnosing those with symptoms to start cancer treatment as early as possible, and (iii) reducing false positive rates during personal health checks," said Dr. Mao. "More importantly, the fact that OncoSeek works well on three different platforms shows its extensibility to other PTM platforms, which will enable more flexible and affordable testing in technologically underdeveloped regions." With the demonstrated performance of OncoSeek on retrospective and prospective cohorts, SeekIn is pursuing additional prospective studies to evaluate performance in different applications. By providing an affordable and effective screening and diagnosis tool, OncoSeek has the potential to save countless lives by detecting and diagnosing cancer at an earlier stage.