On September 28, 2021 Scopus BioPharma Inc. (Nasdaq: "SCPS"), a clinical-stage biopharmaceutical company developing transformational therapeutics for serious diseases with significant unmet medical need, reported that Duet Therapeutics, a wholly-owned subsidiary of Scopus, will release scientific data during the 17th Annual Meeting of the Oligonucleotide Therapeutics Society. The meeting will conclude on Wednesday, September 29, 2021.
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Alan Horsager, Ph.D., President and Chief Executive Officer of Duet and President — Immuno-Oncology of Scopus, will present DUET-01: Bispecific Oligonucleotide Targeting TLR9 and STAT3 Signaling for B Cell Lymphoma Immunotherapy as part of Session VIII: Oligonucleotide Preclinical I.
Dr. Horsager has also presented Bifunctional Oligonucleotides for Systemic Treatment of Immunologically Cold Solid Tumors as an Industry Talk.
Duet has also released a video depicting the mechanism of action for its proprietary CpG-STAT3 inhibitors, which can be viewed here, to coincide with Duet’s presentations at the OTS Meeting.
About the Duet Platform
Duet Therapeutics integrates the immunotherapy assets of Scopus and Olimmune, creating the Duet Platform. Olimmune was acquired by Scopus in June 2021. Duet is a wholly-owned subsidiary of Scopus.
The Duet Platform is comprised of three distinctive, complementary CpG-STAT3 inhibitors:
• RNA silencing CpG-STAT3siRNA ("DUET-01")
• Antisense CpG-STAT3ASO ("DUET-02")
• DNA-binding inhibitor CpG-STAT3decoy ("DUET-03")
DUET-01 is in a Phase 1 clinical trial, as a monotherapy, for B-cell non-Hodgkin lymphoma. Duet expects to file two INDs for DUET-02 in Q4 2022 in genitourinary and head & neck cancers, with clinical Phase 1 trials beginning in Q1 2023 in the United States. Duet is also evaluating combination therapies with checkpoint inhibitors.