On January 5, 2023 Salarius Pharmaceuticals, Inc. (NASDAQ: SLRX), a clinical-stage biopharmaceutical company using targeted protein inhibition and targeted protein degradation to develop therapies for patients with cancer in need of new treatment options,reported that on December 27, 2022 the U.S. Patent and Trademark Office (USPTO) issued U.S. Patent No. 11,535,603, titled "Deuterium-enriched Piperidinonyl-oxoisoindolinyl Acetamides and Methods of Treating Medical Disorders Using Same (Press release, Salarius Pharmaceuticals, JAN 5, 2023, View Source [SID1234626155])." The issued claims cover the composition of matter for novel molecular glue degraders including Salarius’ preclinical cereblon-binding compound, SP-3204, through September 2037.

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Targeted protein degradation (TPD) takes advantage of the body’s own degradation system to promote the selective elimination of disease-causing proteins. The newly issued patent is based on the molecular glue eragidomide (CC-90009) that is known to target the degradation of GSPT1, a protein that is highly expressed in numerous cancers, including hematologic and solid tumors.

David Arthur, President and CEO of Salarius, said, "We are delighted to continue building our TPD portfolio using our deuterium-enabled chiral switching platform to identify and develop potential new therapeutics. SP-3204 is our second novel molecular glue following SP-3164, our lead molecular glue that is expected to enter the clinic later this year. We believe it is important to protect and expand our intellectual property as we advance new drug candidates, and we intend to continue seeking patent protection as our research advances. I extend congratulations to the Salarius team on this important validation of their accomplishments by the USPTO."