Replicate Bioscience Announces Oral Presentations at the 2024 American Society of Gene & Cell Therapy (ASGCT) Annual Meeting

On April 22, 2024 Replicate Bioscience, a clinical-stage company pioneering novel self-replicating RNA (srRNA) technology for use in infectious disease, oncology, autoimmune disease, and more, reported acceptance of two oral presentations at the upcoming American Society of Gene & Cell Therapy (ASGCT) (Free ASGCT Whitepaper) Annual Meeting, May 7-11 in Baltimore, Maryland (Press release, Replicate Bioscience, APR 22, 2024, View Source;cell-therapy-asgct-annual-meeting-302123737.html [SID1234642216]).

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Presentation Details:

The full abstracts are now available through the ASGCT (Free ASGCT Whitepaper) conference website.

Title: Novel Self-Replicating RNA Vectors Broaden Therapeutic Window and Expand Use Outside of Vaccines
Session Title: Emerging Viral Vectors
Location and Time: Ballroom 4, Thursday, May 9, 5:15 PM – 5:30 PM ET
Abstract: 204
Presenter: Parinaz (Paris) Aliahmad
Summary: Ultra-low doses of optimized srRNA vectors achieved immunization with protective antibody titers with minimal reactogenicity in a preclinical influenza model. This broadened therapeutic window presents the opportunity to use these vectors for many clinical applications.

Title: Single and Low Dose Self-Replicating RNA Vaccine Provides Effective Immune Protection Against Rabies in Healthy Volunteers
Session Title: Vector Product Engineering, Development, and Manufacturing (excluding AAV)
Location and Time: Room 314-317, Saturday, May 11, 10:15 AM – 10:30 AM ET
Abstract: 408
Presenter: Zelanna Goldberg
Summary: RBI-4000, an srRNA vector encoding the rabies glycoprotein encapsulated in a lipid nanoparticle, is the first clinical demonstration of next-generation srRNA technology. Interim analysis of a Phase 1 trial demonstrate that all doses were well tolerated and that RBI-4000 was immunogenic at all dose levels tested, conferring protection with a single, low dose.