On September 30, 2021 Repare Therapeutics Inc. ("Repare" or the "Company") (Nasdaq: RPTX), a leading clinical-stage precision oncology company, reported that it has been selected for an oral presentation of initial monotherapy clinical data from its ongoing Phase 1/2 clinical trial of RP-3500 and a poster presentation of preclinical data for RP-3500 at the upcoming AACR (Free AACR Whitepaper)-NCI-EORTC Virtual AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper), being held October 7-10, 2021 (Press release, Repare Therapeutics, SEP 30, 2021, View Source [SID1234590593]). In addition, the Company will be hosting a Virtual Investor Webcast Event on Friday, October 8, 2021 at 5:00 p.m. ET.

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Oral Presentation Details on RP-3500 Early TRESR Monotherapy Trial Results:
Title: First-in-Human biomarker-driven phase I TRESR trial of ataxia telangiectasia and Rad3-related inhibitor (ATRi) RP-3500 in patients (pts) with advanced solid tumors harboring synthetic lethal (SL) genomic alterations
Presenter: Dr. Timothy Yap, MBBS, Ph.D., FRCP, Medical Director, Institute for Applied Cancer Science, Associate Professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, Texas
Abstract Number: 4950
Session Title: Concurrent Session 04: Novel Precision Medicine Combination Trials
Date/Time: Friday, October 8, 2021 at 3:15 p.m. ET

Poster Presentation Details on Preclinical data for RP-3500 Alone and in Combination with PARP Inhibitors:
Title: RP-3500: A Novel, Potent and Selective ATR Inhibitor that is Effective in Pre-Clinical Models as a Monotherapy and in Combination with PARP Inhibitors
Presenter: Anne Roulston, Ph.D., Repare Therapeutics
Poster Number: P054
Date/Time: Thursday, October 7, 2021, at 9:00 a.m. ET

Company Virtual Investor Webcast Event Details:

The Company will host a virtual investor webcast on Friday, October 8, 2021 at 5:00 p.m. ET to further discuss the initial monotherapy RP-3500 data that will be presented at the AACR (Free AACR Whitepaper)-NCI-EORTC Virtual AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper). Repare’s executive management team will be joined by Dr. Timothy Yap, MBBS, Ph.D., FRCP, MD Anderson Cancer Center, Houston, Texas.

A live video webcast and presentation slides will be available on the Investor section of the Company’s website at View Source A webcast replay will also be available for at least 30 days following the call.

About RP-3500

RP-3500 is a potent and selective oral small molecule inhibitor of ATR (Ataxia Telangiectasia and Rad3 related protein kinase) being developed for the treatment of solid tumors with specific genome instability related genomic alterations including those in the ATM (ataxia-telangiectasia mutated) gene.

About Repare Therapeutics’ SNIPRx Platform

Repare’s SNIPRx platform is a genome-wide CRISPR-based screening approach that utilizes proprietary isogenic cell lines to identify novel and known synthetic lethal gene pairs and the corresponding patients who are most likely to benefit from the Company’s therapies based on the genetic profile of their tumors. Repare’s platform enables the development of precision therapeutics in patients whose tumors contain one or more genomic alterations identified by SNIPRx screening, in order to selectively target those tumors in patients most likely to achieve clinical benefit from resulting product candidates.