On December 15, 2022 RenovoRx, Inc. (Nasdaq: RNXT), a biopharmaceutical company focused on the localized treatment of difficult-to-treat solid tumors, reported the acceptance of four clinical data abstracts supporting its lead oncology product candidate, RenovoGem, and its proprietary RenovoRx Trans-Arterial Micro-Perfusion (RenovoTAMP) therapy platform to be presented at the 2023 ASCO (Free ASCO Whitepaper) Gastrointestinal Cancers Symposium (ASCO GI) (Press release, Renovorx, DEC 15, 2022, View Source [SID1234625338]). The Symposium is to be held on January 19-21, 2023 in San Francisco, California and online.

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RenovoGem (gemcitabine, an FDA-approved chemotherapy, delivered via the Company’s proprietary delivery system) utilizes pressure mediated delivery of drug across the arterial wall to bathe tumor tissue in chemotherapy via RenovoTAMP. RenovoGem is currently being evaluated in a Phase III clinical trial in Locally Advanced Pancreatic Cancer (LAPC) patients and the Company plans to investigate RenovoGem in extrahepatic Cholangiocarcinoma (eCCA), beginning in the first half of 2023.

"These research presentations will mark the beginning of a significant year at RenovoRx," said Shaun Bagai, CEO of RenovoRx. "We anticipate continued strong progress on the TIGeR-PaC study with our most significant milestone to date: the first prospective interim analysis of TIGeR-PaC. We also plan to launch a clinical program in extrahepatic Cholangiocarcinoma (bile duct cancer), the second clinical indication for RenovoGem and the RenovoTAMP platform."

"We are excited to present clinical research data generated by some of our investigators of the TIGeR-PaC study at ASCO (Free ASCO Whitepaper) GI," said Ramtin Agah, MD, Chief Medical Officer and Founder of RenovoRx. "These abstracts cover topics relevant to treatment of patients participating in the TIGeR-PaC study. Furthermore, we will also share data regarding the difference in systemic level of gemcitabine using our therapy platform versus the conventional treatment approach for LAPC which is central to our goal of presumed increased efficacy for RenovoTAMP with less systemic side effects."

Poster Presentations Details:

Title: Incidence and Clinical Characteristics of Patients with Locally Advanced Pancreatic Cancer (LAPC) and Mesenteric Vein thrombosis and Current Treatment Paradigm
Authors: Amer H. Zureikat, MD, et al.
Abstract ID: 392418

Title: Intra-arterial Gemcitabine vs IV Gemcitabine PK Sub-study in Patients with Locally Advanced Pancreatic Cancer
Authors: Amer H. Zureikat, MD, et al.
Abstract ID: 394254

Title: Toxicity and Efficacy of Stereotactic Body Radiation Therapy vs. Intensity-modulated Radiation Therapy for the Treatment of Locally Advanced Pancreatic Cancer in a Phase III Trial
Authors: Karyn A. Goodman, MD, et al.
Abstract ID: 392402

Title: Targeted Intra-arterial Gemcitabine vs. Continuation of IV Gemcitabine Plus Nab-paclitaxel Following Induction with Sequential IV gemcitabine Plus Nab-paclitaxel and Radiotherapy for Unresectable Locally Advanced Pancreatic Cancer (TIGeR-PaC): A Randomized Phase III Multi-Center Study (Clinical Trials in Progress)
Authors: Michael J. Pishvaian, MD, et al.
Abstract ID: 393234

About the Phase III TIGeR-PaC Clinical Trial
TIGeR-PaC is a randomized multi-center Phase III study using RenovoRx’s innovative therapy platform, RenovoTAMP (RenovoRx Trans-Arterial Micro-Perfusion). The study is evaluating the Company’s first product candidate, RenovoGem, to treat locally advanced pancreatic cancer (LAPC) through the intra-arterial delivery of gemcitabine (FDA-approved chemotherapy). The study has a primary endpoint of overall survival and several secondary endpoints, including quality of life.

TIGeR-PaC is currently enrolling unresectable LAPC patients at several sites across the US. To learn more about the study and the participating clinical trial sites, visit View Source