On July 29, 2019 Rainier Therapeutics, Inc., a privately held clinical stage drug development company, reported that updated interim results from the FIERCE-22 trial evaluating vofatamab in combination with pembrolizumab in metastatic bladder cancer will be presented at the upcoming European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) 2019 Annual Congress, which will take place September 27 to October 1, 2019 in Barcelona, Spain (Press release, Rainier Therapeutics, JUL 29, 2019, View Source [SID1234537856]).
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"We look forward to presenting updated interim results on clinical activity from our FIERCE-22 trial at ESMO (Free ESMO Whitepaper)," said Scott Myers, Chairman and CEO of Rainier Therapeutics. "This includes longer term follow-up of vofatamab in combination with pembrolizumab in patients with metastatic urothelial carcinoma (bladder cancer), providing a preliminary look at overall survival."
Poster Presentation Details:
Clinical Activity of Vofatamab (V), an FGFR3 Selective Antibody in Combination with Pembrolizumab (P) in Metastatic Urothelial Carcinoma (mUC), Updated Interim Analysis of FIERCE-22
Abstract: 2673
Poster Display Session 3
Presentation Number: 917P
Date: Monday, September 30, 2019
Presentation Time: 12:00 p.m. to 1 p.m.
Location: Poster Area Hall 4
Presenter: Arlene O. Siefker-Radtke, MD, The University of Texas MD Anderson Cancer Center
About FIERCE-22
FIERCE-22 is a Phase 1b/2 trial evaluating vofatamab, a FGFR3-targeted antibody, in combination with pembrolizumab, an immune checkpoint inhibitor, to determine safety, tolerability and preliminary efficacy in the treatment of patients with locally advanced or metastatic bladder cancer who have progressed following platinum-based chemotherapy and who have not received prior immune checkpoint inhibitor therapy.
About Vofatamab
Vofatamab (formerly B-701) is an antibody specifically targeted against the fibroblast growth factor receptor 3 (FGFR3), a known driver of bladder and potentially other FGFR-driven cancers. Vofatamab is the most advanced targeted antibody specific for FGFR3 known by Rainier Therapeutics to be in clinical development. Vofatamab is currently being evaluated in two clinical trials: FIERCE-22 and FIERCE-21.