On July 10, 2024 Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class oncology therapies that overcome tumor immune evasion and drug resistance, reported further details on its virtual key opinion leader (KOL) event on Thursday, July 11, 2024 at 10:30 AM ET (Press release, Purple Biotech, JUL 10, 2024, View Source;id=312421&p=2331411&I=1206939-c7Z3G6f3m8 [SID1234644775]).
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The event will feature Michael Cecchini, MD (Yale School of Medicine) and E. Gabriela Chiorean, MD, FASCO (University of Washington School of Medicine, Fred Hutchinson Cancer Center), who will discuss the positive interim data from the Phase 2 study of CM24, in combination with Bristol Myers Squibb’s immune checkpoint inhibitor nivolumab and standard of care chemotherapy, in second-line metastatic pancreatic ductal adenocarcinoma (PDAC).
The event will also focus on data reported at the 2024 ASCO (Free ASCO Whitepaper) Annual Meeting demonstrating reduced risk of death and progression, prolongation of OS and progression free survival (PFS), higher objective response rate (ORR), disease control rate (DCR) and decreasing CA19-9 levels in the CM24+Nivolumab+Nal-IRI/5FU/LV arm and the new exploratory biomarker data suggesting that baseline serum myeloperoxidase (MPO) may be a predictive biomarker for the treatment effect of CM24-nivolumab therapy on overall survival. CM24 is a humanized monoclonal antibody that blocks the interactions of CEACAM1, a protein expressed on tumor and immune cells, and is a part of the Neutrophils Extra Cellular Traps (NETs), involved in tumor immune evasion and survival through multiple pathways.
Management will discuss Purple Biotech plans for CM24.
A live question and answer session will follow the formal presentation.
About Michael Cecchini, MD
Michael Cecchini, MD is an Assistant Professor of Medicine (Medical Oncology) at the Yale Cancer Center in the Yale University School of Medicine. He is a board-certified medical oncologist that specializes in the treatment of patients with advanced gastrointestinal (GI) cancers. His research is focused on early phase clinical trials to develop novel therapies that are biomarker driven for patients with advanced gastrointestinal cancers. Furthermore, he performs translational research to better understand the relationship between DNA damage and the immune response to develop new biomarkers and treatment combinations for patients with advanced GI cancers. Dr. Cecchini is also the co-director of the Colorectal Cancer Program in the Yale Center for GI Cancers and is also a member of the National Cancer Institute Colon Task Force. Dr. Cecchini has served as an investigator on numerous clinical trials and has authored multiple manuscripts evaluating novel treatment combinations in advanced cancer.
About E. Gabriela Chiorean, MD, FASCO
E. Gabriela Chiorean, MD, FASCO is a GI and Phase I Medical Oncologist, Professor of Medicine at University of Washington (UW) Division of Medical Oncology, and Professor in the Clinical Research Division at the Fred Hutchinson Cancer Center (Fred Hutch) in Seattle, WA. Dr. Chiorean is the Medical and Clinical Research Director of the UW/Fred Hutch Gastrointestinal Oncology Program, and Deputy Co-Director of the Fred Hutch Pancreatic Cancer Program. She is Vice-Chair of the GI Cancers Committee for the NCI Southwest Oncology Cooperative Group (SWOG) Cancer Research Network, and member of the NCI Gastrointestinal Cancers Steering Committee (GISC) Pancreatic Cancer Task Force. She is also a member of the National Comprehensive Cancer Network (NCCN) Guidelines Panel for Pancreatic Cancers, and leader of the NCCN Guidelines Panel for Ampullary Cancers. She is the chair of the ASCO (Free ASCO Whitepaper) Plenary Series for GI Cancers, chaired multiple ASCO (Free ASCO Whitepaper) Scientific Committees for GI Cancers and Developmental Therapeutics, and co-chaired the ASCO (Free ASCO Whitepaper) international expert panel for Late-Stage Colorectal Cancer Guidelines. Dr Chiorean has authored over 100 peer reviewed research publications in journals such as Science, New England Journal of Medicine, Journal of Clinical Oncology, Lancet Oncology, JAMA Oncology and Annals of Oncology. Dr. Chiorean’s clinical and translational research interests for pancreatic and gastrointestinal cancers are focused on biomarker driven precision oncology, adoptive cellular immunotherapies, and novel therapeutics.