On March 5, 2025 Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance, reported that the U.S. Patent and Trademark Office has issued a patent for NT219 used in combination with epidermal growth factor receptor (EGFR) antibodies for treating cancer patients who have acquired resistance to EGFR therapies (Press release, Purple Biotech, MAR 5, 2025, View Source [SID1234650905]). The patent, titled "Combinations of IRS/STAT3 dual modulators and anti-cancer agents for treating cancer" addresses NT219 in combination with cetuximab (Erbitux) as well as other EGFR antibodies such as panitumumab (Vectibix) and necitumumab (Portrazza) in treating tumors resistant to EGFR therapy and in preventing or delaying cancer tumor recurrence following cessation of treatment with an EGFR therapy.
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Purple Biotech’s NT219 is a first-in-class small molecule drug designed to target key cancer resistance mechanisms by degrading IRS1/2 and blocking IGF1R/IRS1 and STAT3 survival pathways.
NT219 recently advanced into a Phase 2 study in second-line patients with recurrent and/or metastatic head and neck cancer to evaluate the drug in combination with standard-of-care head and neck cancer therapies, including cetuximab and pembrolizumab. The head and neck cancer treatment market is forecast to reach $5 billion by 2030.
"This latest U.S. patent completes geographic patent protection of NT219 used in combination with cetuximab in major markets such as the United States, Europe, China and Japan," stated Gil Efron, Purple Biotech CEO. "We believe this additional patent strongly positions us for the potential future commercialization of our novel NT219 therapy."
Purple Biotech’s growing intellectual property portfolio for NT219 in combination with anti-cancer standard-of-care therapies includes a previously issued U.S. patent that covers the pharmaceutical combinations of NT219 with small molecule EGFR inhibitors. This patent has also been granted or allowed in major markets.