On April 14, 2025 ProBio, a global leader in the antibody discovery and development, reported its upcoming poster presentation at the American Association for Cancer Research (AACR) (Free AACR Whitepaper)Ⓡ (AACR) (Free AACR Whitepaper) 116th Annual Meeting, to be held April 25 to 30, 2025, at the McCormick Place Convention Center in Chicago, Illinois (Press release, ProBio, APR 14, 2025, View Source [SID1234651915]).
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"We are excited to present our pre-clinical findings at the AACR (Free AACR Whitepaper), showcasing the significant potential of our CD3 agonistic single-domain antibody," said Allen Guo, CEO. "This platform offers a unique combination of potency, design flexibility, and a favorable safety profile, making it an ideal foundation for developing highly effective bispecific and multi-specific antibodies for various cancers."
ProBio will showcase pre-clinical in vitro and in vivo data demonstrating the potential of its innovative CD3 agonistic single-domain antibody (sdAb/VHH) as a foundational component for advancing the development of next-generation T cell engager (TCE) bispecific and multi-specific antibodies. This format offers a unique combination of potency, design flexibility, and a favorable safety profile—addressing key limitations of traditional CD3 binders in immuno-oncology.
Presentation Details
Title: The Discovery and Development of a CD3 Agonistic Single Domain Antibody to Accelerate the Development of CD3 T Cell Engager Multi-Specific Antibodies
Session Title: Therapeutic Antibodies, Including Engineered Antibodies 2
Session Date and Time: April 29, 2025 at 2-5 PM
Location: Poster Section 35
Poster Board Number: 1
Published Abstract Number: 6006
View Abstract: View Source!/20273/presentation/1890
About ProBio’s T-Cell Engager and Antibody Discovery Platform
CD3 T-cell engagers (TCEs) are a promising strategy in cancer immunotherapy, that are often constrained by safety concerns, potency limitations, and design challenges. ProBio’s proprietary platform utilizes an optimized single-domain antibody (sdAb) targeting CD3, overcoming these challenges by enablingthe development of highly adaptable bispecific and multi-specific antibodies. These antibodies show enhanced tumor-killing activity and improved safety profiles. Preclinical studies have demonstrated robust T-cell activation, tumor growth inhibition, and overall therapeutic potential.
ProBio’s approach is supported by a fully integrated Contract Development and Manufacturing Organization (CDMO) model that spans discovery through IND-enabling studies with scalable Chemistry, Manufacturing, and Controls (CMC) development and GMP drug product manufacturing. This seamless approach allows biotech and pharmaceutical partners to transition efficiently from early-stage concepts to clinical and commercial production, reducing development risks and accelerating timelines.
"Our CD3 single-domain antibody platform represents the innovation needed to address some of most pressing challenges in immune-oncology – delivering potent, modular, and clinically translatable solutions," said Dr. Yu Liang, Head of Discovery at ProBio. "By combining deep scientific expertise with end-to-end development capabilities, we’re accelerating the pace at which our partners can bring transformative immunotherapies to the clinic."
ProBio remains committed to partnering with global innovators to accelerate the development of novel immunotherapies, advancing the standard of care for both solid and liquid tumors.