On April 14, 2016-Presage Biosciences, an oncology company that has established a novel drug development approach to assess drug combinations directly in patient tumors, reported that is has entered into a multi-year extension of its November 2014 research alliance with Takeda Pharmaceuticals Company Limited (TSE:4502) (Press release, Presage Biosciences, APR 14, 2016, View Source [SID:1234510837]). Schedule your 30 min Free 1stOncology Demo! The agreement provides Takeda access to Presage’s proprietary CIVO technology platform to enable identification of novel oncology drug combinations in solid tumors. Under the agreement, Presage and Takeda will screen a broad array of drug combinations and preclinical models to discover novel combinations and generate data to support clinical decision-making on Takeda’s pipeline agents. The agreement includes development and regulatory milestones related to identification of successful novel drug combinations.
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
"We are pleased to extend our collaboration with Presage and utilize their technology platform to more rapidly understand the impact of drug combinations directly on tumors," said Christopher Claiborne, Ph.D., Head of the Oncology Drug Discovery Unit at Takeda. "Takeda prides itself on creating novel medicines for patients, and having a committed partner like Presage enables us to continue fulfilling our mission of aspiring to cure cancer."
"It is deeply rewarding to continue our collaboration with Takeda," said Richard Klinghoffer, Chief Scientific Officer of Presage. "Together, the teams at Presage and Takeda are employing the unique potential of Presage’s CIVO arrayed microinjection technology to identify novel drug combinations that will hopefully improve the lives of patients with cancer."
CIVO technology is currently being used preclinically to identify effective combinations of drugs. By assessing several combinations in a single living tumor, the CIVO platform is able to characterize and directly compare the influence of multiple biophysical factors such as immune infiltrate, stromal barrier and hypoxia on the tumor response.