On July 22, 2021 Plus Therapeutics, Inc. (Nasdaq: PSTV) (the "Company"), a clinical-stage pharmaceutical company developing innovative, targeted radiotherapeutics for rare and difficult-to-treat cancers, reported the first patient in the eighth cohort of the Phase 1 dose escalation ReSPECT-GBM clinical trial for recurrent glioblastoma (rGBM) has been successfully treated (Press release, Cytori Therapeutics, JUL 22, 2021, View Source [SID1234585090]). The present cohort implements a 40% increase in volume (12.3 milliliters) and total radioactivity (31.2 millicuries) from the previous cohort.

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"The ReSPECT-GBM Phase 1 clinical trial is progressing on schedule and with an acceptable safety profile," said Marc H. Hedrick M.D., President and Chief Executive Officer of Plus Therapeutics. "We plan to provide an update on the trial in the fourth quarter of 2021."

Twenty-two patients across eight dosing cohorts have been treated in the ReSPECT trial to date. Thus far, no treatment emergent dose-limiting toxicities have been observed, despite absorbed radiation doses to the tumor of up to 740 Gray.