On August 28, 2023 Perspective Therapeutics, Inc. ("Perspective" or "the Company") (NYSE AMERICAN: CATX), reported that it will present new clinical and preclinical data for 212Pb-VMT-α-NET, a Targeted Alpha-Particle Therapy, at the upcoming 36th Annual Congress of the European Association of Nuclear Medicine (EANM) (Press release, Perspective Therapeutics, AUG 28, 2023, View Source [SID1234634716]). The conference is being held in Vienna, Austria, from September 9-13, 2023.

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"Our team at Perspective Therapeutics continues to work diligently to advance much needed targeted alpha therapy using 212Pb," said Thijs Spoor, Chief Executive Officer at Perspective Therapeutics. "We are particularly excited about the early clinical results from 212Pb-VMT-α-NET in patients suffering from different types of difficult-to-treat neuroendocrine tumors. These results support our belief that targeted alpha therapies have the potential to revolutionize our approach to eliminating cancers and intractable tumors."

"We are excited to have early results presented by Dr. Dharmender Malik of Fortis Memorial research institute on the safety and efficacy of 212Pb-VMT-α-NET especially in patients with somatostatin receptor positive, metastatic neuroendocrine and medullary thyroid tumors," said Markus Puhlmann, MD, MBA, Chief Medical Officer at Perspective Therapeutics. "Additionally, we will present data from our metastatic mouse model of neuroblastoma exploring the efficacy of 203/212Pb-VMT-α-NET for image-guided treatment in this metastatic neuroblastoma tumor model."

Details about these presentations can be found below and on the EANM website (eanm23.eanm.org). Additionally, copies of the abstracts can be found in the EANM ’23 Abstract Book on the EANM website.

Presentation One:

This presentation will discuss early clinical results from the study of 212Pb-VMT-α-NET in ten patients with somatostatin receptor (SSTR)-expressing progressive neuroendocrine tumors and metastatic medullary thyroid carcinomas. 212Pb-VMT-α-NET demonstrated an encouraging safety profile and treatment resulted in partial responses in a number of patients.

Title: Early results of 212Pb-VMT-α-NET Targeted Alpha Therapy in Metastatic Gastro-entero-pancreatic Neuroendocrine Tumors: First in Human Clinical Experience on Safety and Efficacy
Session: Theranostics Track – What’s New in Endocrine Tumors
Abstract Number: OP-673
Presenter: D. Malik, Consultant Nuclear Medicine and PET-CT, MBBS, DNB, FANMB & RSO-II at Fortis Memorial research institute (FMRI), Gurugram, India at Fortis Healthcare Pvt.
Details: Tuesday, September 12, 2023, 9:45 a.m. CEST
Location: Hall G1

Presentation Two:

This presentation will discuss the effective tumor control of fractionated doses of [212Pb]VMT-α-NET demonstrated in a mouse model of high-risk metastatic neuroblastoma. The data showed that fractionated doses of [212Pb]VMT-α-NET provided greater benefit than single dose administration of [212Pb]VMT-α-NET.

Title: Preclinical Evaluation of [212Pb]VMT-α-NET Targeted Alpha Therapy for High-Risk Metastatic Neuroblastoma
Session: M2M Track: Radioligand Therapy – New and Old Targets
Abstract Number: OP-144
Presenter: D. Liu, Principal Research Scientist, Perspective Therapeutics, Inc.
Details: Session 504, Sunday, September 10, 2023, 3.00 p.m. CEST
Location: Hall E2