Transgene Successfully Raises € 14.4 Million from U.S. and European Investors

On November 9, 2017 Transgene (Paris:TNG)("Transgene" or the "Company"), a biotech company that designs and develops viral-based immunotherapies, reported the success of its capital increase without preferential subscription rights for an amount of € 14.4 million by means of a private placement of new shares via an accelerated book-build offering (Press release, Transgene, NOV 10, 2017, View Source [SID1234521916]).

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The transaction, announced on November 9, 2017, was oversubscribed, at € 2.55 per share, and represents 10 % of the issued share capital of the Company (and 5,643,199 new shares). This represents the maximum capital increase the Company could undertake under the relevant financing resolutions.

Qualified U.S. and European institutional investors, including those specialized in biotechnology have participated in the private placement, reinforcing the Company’s international shareholding structure.

Philippe Archinard, Chairman and Chief Executive Officer of Transgene, said: "The success of this capital raise demonstrates growing appreciation of Transgene’s position as a global leader in the immuno-oncology field. The Company expects to deliver numerous key value-creating milestones in the next 12 months as we progress on our innovative portfolio of five clinical-stage immunotherapy products as well as our strong research capabilities. We would like to thank the specialized healthcare investors, both in the U.S. and Europe, that have participated to this transaction together with Institut Mérieux. This private placement allows us to reinforce our cash position and diversify our shareholder base."

Guggenheim Securities, LLC and Oddo BHF SCA acted as Joint Bookrunners.

Key highlights of the offering

The capital increase was conducted by way of a private placement of new shares via an accelerated book-build offering announced on November 9, 2017. The issue price of the new shares has been set at € 2.55 per share, representing a 18.6 % discount to the volume weighted average of the closing prices of the Company’s shares on the regulated market of Euronext Paris of the last 3 trading sessions preceding the pricing (that being November 7, 2017, November 8, 2017 and November 9, 2017, inclusive), which was € 3.1342.

The new shares have been placed with investors in the United States and Europe. The book order was well covered based on strong demand from new and existing investors, including Institut Mérieux (TSGH), the majority shareholder of the Company, and Dassault Belgique Aviation (DBA), an existing shareholder.

The new shares, representing 10 % of the issued share capital of the Company prior to the share capital increase, were issued pursuant to the delegation of authority granted to the Board of Directors under the 17th and 18th resolutions of the extraordinary general meeting of the shareholders of the Company dated June 8, 2017, and in accordance with articles L. 225-136 of the French Commercial code (code de commerce) and L. 411-2(II) of the French monetary and financial code (code monétaire et financier).

On an illustrative basis, a shareholder holding 1% of Transgene’s capital before the offering will now hold a stake of 0.91 %. The majority shareholder, TSGH has subscribed 28 % of the new shares and DBA has subscribed 2.9 % of the new shares and their respective subscriptions have been fully allocated. On this basis, after completion of the capital increase, TSGH will hold 57.1 % of the share capital of the Company (and 67.2 % of the voting rights) and DBA will hold 4.7 % of the share capital of the Company (and 3.6 % of the voting rights).

21 new investors have subscribed 69 % of the new shares, representing 6.3 % of the share capital of the Company.

Use of proceeds

The funds raised will be used to pursue the clinical and preclinical development of Transgene’s innovative immunotherapies in combination with immune checkpoint inhibitors, to deliver improved treatment outcomes, as well as for working capital and for general corporate purposes.

This transaction will extend Transgene’s financial visibility through mid-2019. Net proceeds will reinforce the cash position of the Company which amounted to €40.0 million in consolidated cash reserves as of September 30, 2017.

Admission to listing of the new shares

The new shares will have a par value of one euro each, carry dividend rights as from their issue date and be immediately fungible in all respects with the Company’s existing shares. Settlement and delivery of the new shares and the new shares’ admission to trading are expected to occur on November 14, 2017 on the regulated market of Euronext in Paris.

They will be admitted to trading under the same code as the existing shares (ISIN FR0005175080) on November 14, 2017 on the regulated market of Euronext in Paris.

The transaction is not subject to a prospectus to be approved by the French financial markets authority (Autorité des marchés financiers).

Standstill and lock-up provisions

The Company, Institut Mérieux, and Dassault Belgique Aviation have entered into a lock-up agreement ending 90 calendar days after the closing date of the offering, subject to certain customary exceptions. Certain executives and directors of the Company have also signed lock-up agreements with regard to the Company’s shares that they hold, for the same period.

Risk factors

Attention is drawn to the risk factors related to the Company and its activities presented in section 1.4 of the 2016 reference document filed with the Autorité des marchés financiers on April 13, 2017, under number D.17-385, which is available on the Autorité des marchés financiers website (www.amf-france.org) or on the Company’s website (www.transgene.fr).

Trillium Therapeutics Reports Third Quarter 2017 Financial and Operating Results

On November 10, 2017 Trillium Therapeutics Inc. (NASDAQ/TSX: TRIL), a clinical stage immuno-oncology company developing innovative therapies for the treatment of cancer, reported financial results for the nine months ended September 30, 2017 (Press release, , NOV 10, 2017, View Source [SID1234521942]).

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"Our strategy of running intravenous and intratumoral signal-seeking Phase 1 trials of TTI-621 in multiple indications gives us the best opportunity to identify malignancies where we can further focus our clinical efforts," said Dr. Niclas Stiernholm, Trillium’s Chief Executive Officer. "We are on track to provide additional clinical updates by year end."

Upcoming Clinical Events in the Fourth Quarter of 2017:

Preliminary data from the TTI-621 Phase 1a intratumoral dose escalation trial in solid tumors to be presented at the American Society of Hematology (ASH) (Free ASH Whitepaper) 59th Annual Meeting
Additional clinical data from the TTI-621 Phase 1b intravenous trial to be presented at the American Society of Hematology (ASH) (Free ASH Whitepaper) 59th Annual Meeting
IND submission for TTI-622
Third Quarter 2017 Financial Results

As of September 30, 2017, Trillium had cash and marketable securities of $64.3 million compared to $50.5 million at December 31, 2016. The increase in cash and marketable securities was due mainly to receiving net proceeds of $39.0 million from the June 2017 financing, partially offset by cash used in operations of $20.4 million and an unrealized foreign exchange loss of $4.5 million.

Net loss for the nine months ended September 30, 2017 of $34.4 million was higher than the loss of $22.7 million for the nine months ended September 30, 2016. The net loss was higher due mainly to higher research and development expenses of $6.8 million with two active Phase 1 trials for TTI-621 and manufacturing expenses for TTI-622 in 2017, the recognition of a deferred tax recovery in the nine months ended September 30, 2016 related to the acquisition of Fluorinov of $3.7 million, and a higher net foreign currency loss of $1.8 million.

Five Prime Therapeutics Presents Poster on FGFR2b Expression and Immune Signature in Urothelial Cancer at the Society for Immunotherapy of Cancer 32nd Annual Meeting

On November 10, 2017 Five Prime Therapeutics, Inc. (Nasdaq:FPRX), a clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics, reported that analyses of FGFR2b expression and baseline immune signature in urothelial cancer (UC) samples were featured in a poster presentation at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 32nd Annual Meeting, being held November 8-12, 2017 in National Harbor, Maryland (Press release, Five Prime Therapeutics, NOV 10, 2017, View Source [SID1234521937]). A PDF of the poster, "FGFR2b Expression and Baseline Immune Signature to Guide FPA144 Development in Urothelial Cancer," will be made available on the Publications page of the Five Prime website. Five Prime is developing FPA144, an isoform-selective antibody, as a targeted immunotherapy for tumors that overexpress FGFR2b. Five Prime continues to enroll patients in the Phase 1 trial cohort evaluating FPA144 as a treatment for patients with bladder cancer whose tumors overexpress FGFR2b.

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"Profiling FGFR2b expression and baseline tumor-associated immune cells could help guide our clinical development strategy for FPA144 in bladder cancer," said Kevin Baker, Ph.D., Senior Vice President, Development Sciences at Five Prime. "Previously we showed in a pre-clinical model with moderate FGFR2b expression, that FPA144 can reprogram the tumor microenvironment making it more inflammatory. In the same studies, we also showed that FPA144 and PD-1 blockade have additive anti-tumor effects."

Five Prime evaluated FGFR2b expression in 387 archival primary early stage UC samples and previously reported that > 10% had overexpression of FGFR2b by immunohistochemistry (IHC) with intensity level of at least 1+. The research team selected 32 archival UC cases with a range of FGFR2b expression (62% were FGFR2b positive) and characterized baseline immune composition in the tumor microenvironment and the relationship with FGFR2b expression to potentially guide FPA144 development in combination with other therapies.

The results from the selected cases suggest that FGFR2b is expressed in all immune subtypes of UCs, but the expression level varies. The highest level of expression is in inflamed and more proliferative UCs. The Company plans to evaluate additional archival UC tissues from patients with more advanced metastatic disease to determine if there is an association of FGFR2b expression with baseline immune signature in late-stage patient tumors.

Halozyme To Present Nonclinical Data At SITC 2017 Supporting Combination Of PEGPH20 With Checkpoint Inhibitors

On November 10, 2017 Halozyme Therapeutics, Inc. (NASDAQ: HALO) reported that it will present nonclinical data at the 32nd Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) which demonstrate the potential for PEGPH20, Halozyme’s pegylated recombinant human hyaluronidase, to increase the infiltration of immune cells into the tumor microenvironment and enhance the efficacy of immuno-oncology drugs in an HA-accumulating murine colon tumor model (Press release, Halozyme, NOV 10, 2017, View Source [SID1234521938]).

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The study shows that degradation of hyaluronan (HA) in a tumor by PEGPH20 can facilitate an anti-tumor immune response induced by checkpoint blockade by promoting effector cell infiltration and skewing the immune microenvironment toward a more anti-tumor composition. The data support Halozyme’s ongoing clinical evaluation of PEGPH20 in combination with checkpoint inhibitors.

The poster, entitled "Degradation of hyaluronan by PEGPH20 promotes anti-tumor immunity and enhances the effect of checkpoint blockade in an HA-accumulating mouse syngeneic tumor model," will be presented as part of a series of posters focusing on the tumor microenvironment from 12:30 p.m. to 2 p.m. EST on Saturday, November 11.

Northern Presents Phase 1 Trial Poster at SITC Conference

On November 10, 2017 Northern Presented Phase 1 Trial Poster at SITC (Free SITC Whitepaper) Conference.(Presentation, Northern Biologics, NOV 10, 2017, View Source [SID1234521940])

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