Onconova Therapeutics to Present at Biotech Showcase in January

On December 28, 2017 Onconova Therapeutics, Inc. (NASDAQ:ONTX), a Phase 3-stage biopharmaceutical company focused on discovering and developing novel products to treat cancer, with a primary focus on myelodysplastic syndromes (MDS), reported that it will present at Biotech Showcase taking place January 8-10 in San Francisco (Press release, Onconova, DEC 28, 2017, View Source [SID1234522785]). The Company’s CEO and President, Dr. Ramesh Kumar, will present and management will be available for one-on-one meetings.

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Presentation Details:

Date: Tuesday, January 9th, 2018

Time: 2:00 pm PDT (5:00 pm EST)

Location: Franciscan Room B at the Hilton San Francisco Union Square, 333 O’Farrell Street – Ballroom Level

The presentation will be available on the Investors section of the Company’s website at: View Source

Propanc Biopharma to Present at the 10th Annual Biotech Showcase™ 2018

On December 28, 2017 Propanc Biopharma Inc. (OTCQB: PPCB) ("Propanc Biopharma" or "the Company"), a clinical stage biopharmaceutical company focusing on development of new and proprietary treatments for cancer patients suffering from solid tumors such as pancreatic, ovarian and colorectal cancers, reported that the Company’s Chief Executive Officer, Mr James Nathanielsz, reported that it will be presenting at the 10th Annual Biotech Showcase to be held on January 8 – 10, 2018, at the Hilton, Union Square, San Francisco, CA (Press release, Propanc, DEC 28, 2017, View Source [SID1234522786]). The Company’s presentation is scheduled for Wednesday, January 10, 2018, at 10:30 a.m., PST.

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Mr Nathanielsz will provide an overview of the Company and recent advancements of its lead product, PRP, during the live presentation and will be available to participate in one-on-one meetings with attendees who are registered to attend the conference.

Additionally, Mr Nathanielsz will be available to participate in investor and partnering meetings surrounding the 36th Annual J.P. Morgan Healthcare Conference to be held January 8-11, 2018 in San Francisco, CA. Investors are encouraged to contact [email protected] to request a meeting.

"I am looking forward to presenting at the upcoming conference and providing an update on the recent developments of PRP, as we prepare for filing our first clinical trial application in early 2018," said Mr Nathanielsz.

Currently progressing towards First-In-Human studies, PRP aims to prevent tumor recurrence and metastasis from solid tumors. Eighty percent of all cancers are solid tumors and metastasis is the main cause of patient death from cancer. According to the World Health Organization, 8.2 million people died from cancer in 2012. Consequently, a report by IMS Health states innovative therapies are driving the global oncology market to meet demand, which is expected to reach $150 billion by 2020. The Company’s initial target patient populations are pancreatic, ovarian and colorectal cancers, representing an estimated combined market segment of $14 billion in 2020, according to GBI Research.

To view Propanc Biopharma’s "Mechanism of Action" video on anti-cancer product candidate, PRP, please click on the following link: View Source

To be added to Propanc Biopharma’s email distribution list, please click on the following link: View Source and submit the online request form.

About Biotech Showcase:
Biotech Showcase is an investor and networking conference devoted to providing private and public biotechnology and life sciences companies with an opportunity to present to, and meet with, investors and pharmaceutical executives in one place during the course of one of the industry’s largest annual healthcare investor conferences. Investors and biopharmaceutical executives from around the world gather in San Francisco during this bellwether week which sets the tone for the coming year.

LIDDS: NanoZolid® with immune-stimulating agent demonstrates significant efficacy

On December 27, 2017 LIDDS reported that it has successfully completed the first steps in one of its projects assessing the feasibility of using the NanoZolid drug delivery technology for intratumoral immunotherapy with positive results (Press release, Lidds, DEC 27, 2017, View Source [SID1234555921]).

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In one of LIDDS immune-oncology projects, an immune-stimulatory agent was successfully formulated using the NanoZolid drug delivery technology. Chemical analytical methods demonstrated that the agent had a very promising release profile from the drug formulation. In a second step, the NanoZolid formulated immune-stimulatory agent was tested in an immuno-oncology model of a aggressive/hard to treat cancer in mice. In this model, a single dose of the locally delivered immunotherapy significantly reduced tumour growth and increased survival in the treated animals compared to control animals.

This demonstrates that that the NanoZolid drug delivery technology can be leveraged to develop novel immunotherapies that can act locally or intratumorally.

A locally delivered immunotherapy has the potential to act either as a monotherapy or in combination with systemic immunotherapies e.g. checkpoint inhibitors. A successful combination treatment could significantly increase the response rates and efficacy rates of current immunotherapies.

A recent review article in the highly ranked journal Annals of Oncology (Impact Factor 11.855) highlights the unique opportunity of intratumoral treatments to increase the efficacy of immunotherapy while reducing the potential side-effects.

Results from the other preclinical feasibility studies are expected in the first quarter of 2018.

Immunotherapy for the treatment of cancer aims to activate and utilize the body’s own immune system to recognize and attack tumors and cancer cells and is today the fastest growing and most promising area of cancer research.

KAZIA THERAPEUTICS LIMITED AND NOXOPHARM LIMITED

On December 27, 2017 Kazia Therapeutics Limited (ASX: KZA, NASDAQ: KZIA) and Noxopharm Limited (ASX: NOX) reported the creation of a collaboration to support the future development of the Noxopharm lead program, NOX66 (Press release, Kazia Therapeutics, DEC 27, 2017, View Source [SID1234538107]).

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Under the terms of the collaboration, Kazia will provide certain technical information and related proprietary information that is expected to assist and expedite the successful development of NOX66. In return, Kazia has agreed to take a small equity interest in Noxopharm, which will help to align the future interests of both companies.

Kazia CEO, Dr James Garner, commented, "we are delighted to facilitate the future success of NOX66, and we look forward to assisting and following the progress of the program with keen interest."

Noxopharm CEO, Dr Graham Kelly, commented, "the collaboration with Kazia helps to ensure that the major clinical program planned in 2018 for NOX66 will proceed smoothly and with certainty. We look forward to providing our shareholders with data as the various clinical studies progress."

Oncolytics Biotech® Announces Poster Presentation at the 2018 Gastrointestinal Cancers Symposium Sponsored by ASCO in Patients with Relapsed Metastatic Adenocarcinoma of the Pancreas

On December 27, 2017 Oncolytics Biotech Inc. (TSX: ONC) (OTCQX: ONCYF) (Oncolytics or the Company), a biotech company developing REOLYSIN, also known as pelareorep, an intravenously delivered immuno-oncolytic virus that activates the innate and adaptive immune systems to turn ‘cold’ tumors ‘hot’, reported that data from REO 024 will be presented at the 2018 Gastrointestinal Cancers Symposium sponsored by ASCO (Free ASCO Whitepaper), January 18 – 20, 2018, in San Francisco (Press release, Oncolytics Biotech, DEC 27, 2017, View Source [SID1234522782]). The poster presentation by Dr. Devalingam Mahalingam, M.D. Ph.D., Associate Professor of Medicine (Hematology and Oncology) at the Feinberg School of Medicine, Northwestern University, will present clinical data evaluating intravenous administration of pelareorep in combination with pembrolizumab (KEYTRUDA) and chemotherapy in patients with advanced or metastatic pancreatic adenocarcinoma.

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"I’m thrilled that Dr. Mahalingam will have the opportunity to present data from the REO 024 study combining pelareorep with Merck’s Keytruda and chemotherapy," said Dr. Matt Coffey, President and CEO of Oncolytics Biotech. "While our focus remains on metastatic breast cancer, we continue to be very interested in the potential to treat pancreatic cancer patients. Our NCI-8601 study demonstrated an increase in landmark survival at two years in pancreatic patients from nine percent to twenty percent, when comparing pelareorep plus carboplatin to carboplatin alone. Our REO 017 study improved overall two-year survival in pancreatic patients from historical measures of four to five percent to twenty-four percent, when comparing pelareorep plus gemcitabine to gemcitabine alone. We believe there is an obvious therapeutic effect in pancreatic cancer and look forward to this presentation in January."

Abstract number: 283
Title: A study of pelareorep in combination with pembrolizumab and chemotherapy in patients (pts) with relapsed metastatic adenocarcinoma of the pancreas (MAP)

Poster Session: Session B: Cancers of the Pancreas, Small Bowel, and Hepatobiliary Tract

Date/Time: January 19, 11:30 AM-1:00 PM; 5:30 PM-6:30

About REOLYSIN/Pelareorep
REOLYSIN, also known as pelareorep, is a non-pathogenic, proprietary isolate of the unmodified reovirus: a first-in-class intravenously delivered immuno-oncolytic virus for the treatment of solid tumors and hematological malignancies. The compound induces selective tumor lysis and promotes an inflamed tumor phenotype through innate and adaptive immune responses to treat a variety of cancers.