Heat Biologics, Inc. Announces Proposed Public Offering

On November 20, 2018 HEATBIOLOGICS, INC. (NASDAQ: HTBX), a biopharmaceutical company developing immunotherapies with the goal of activating a patient’s immune system against cancer through T-cell activation, reported that it intends to offer for sale its common stock and warrants to purchase shares of its common stock in an underwritten public offering (Press release, Heat Biologics, NOV 20, 2018, View Source [SID1234531538]). Heat Biologics, Inc. intends to use the net proceeds from this offering to fund, among other things, its and its subsidiaries’ preclinical and clinical programs and for working capital and general corporate purposes, including, to acquire, license or invest in complementary businesses, technologies, product candidates or other intellectual property. The offering is subject to market conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

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A.G.P./Alliance Global Partners is acting as sole book-running manager for the offering.

This offering is being made pursuant to an effective shelf registration statement on Form S-3 (No. 333-221201) previously filed with the U.S. Securities and Exchange Commission (the ”SEC”). A preliminary prospectus supplement and accompanying prospectus describing the terms of the proposed offering will be filed with the SEC and will be available on the SEC’s website located at View Source Electronic copies of the preliminary prospectus supplement may be obtained, when available, from A.G.P./Alliance Global Partners, 590 Madison Avenue, 36th Floor, New York, NY 10022 or via telephone at 212-624-2006 or email: [email protected]. Before investing in this offering, interested parties should read in their entirety the prospectus supplement and the accompanying prospectus and the other documents that Heat Biologics, Inc. has filed with the SEC that are incorporated by reference in such prospectus supplement and the accompanying prospectus, which provide more information about Heat Biologics, Inc. and such offering.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Akebia Therapeutics to Participate in Upcoming Investor Conferences

On November 20, 2018 Akebia Therapeutics, Inc. (Nasdaq: AKBA), a biopharmaceutical company focused on delivering innovative therapies to patients with kidney disease through the biology of hypoxia-inducible factor (HIF), reported that it will participate in the following investor conferences (Press release, Akebia, NOV 20, 2018, View Source [SID1234531537]):

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The 30th Annual Piper Jaffray Healthcare Conference onWednesday, November 28, 2018, at 12:30 p.m. Eastern Time at the Lotte New York Palace Hotel. Akebia will participate in a fireside chat discussion; and
The Global Mizuho Investor Conference on Monday, December 3, 2018, at the Lotte New York Palace Hotel.
A replay of the webcast from the Piper Jaffray Healthcare Conference will be available on the company’s website at www.akebia.com the day following the conference. To access, please log onto the Akebia website at least 15 minutes prior to the webcast to ensure adequate time for any software downloads that may be required.

Mirati Therapeutics To Present At The 30th Annual Piper Jaffray Healthcare Conference

On November 20, 2018 Mirati Therapeutics, Inc. (NASDAQ: MRTX), a clinical stage targeted oncology company, reported that it will participate in a fireside chat at the 30th Annual Piper Jaffray Healthcare Conference in New York on Tuesday, November 27th at 12:30 p.m. EST/ 9:30 a.m. PST. Charles M. Baum, M.D., Ph.D., President and Chief Executive Officer will represent Mirati at the conference (Press release, Mirati, NOV 20, 2018, View Source [SID1234531534]).

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The presentation will be webcast and made available through the "Investors" section of www.mirati.com, and replays will be made available for 90 days following the events.

Cernostics Secures Additional Patents for Proprietary Barrett’s Esophagus Clinical Diagnostics

On November 20, 2018 Cernostics, developer of next-generation cancer diagnostics and prognostics, reported that it has received a U.S. Patent and a European Notice to Grant for the company’s TissueCypher Barrett’s Esophagus Assay, adding protection to previously awarded foundational, platform patents granted in 2014 (Press release, Cernostics, NOV 20, 2018, View Source [SID1234531530]).

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Earlier this month, Cernostics received notification from the European Patent Office that claims will be issued for its patent entitled "Systems and Compositions for Diagnosing Barrett’s Esophagus and Methods for Using the Same." This notice comes on the heels of a recent issuance of a corresponding U.S. patent (U.S. Patent No. 10,018,631).

Cernostics’ recent patent claims relate to the company’s clinical test for predicting disease progression in patients with BE and assessment of the likelihood that BE may further develop into esophageal adenocarcinoma (EAC). The patents support a multiplexed evaluation of how protein biomarkers are expressed in various gastrointestinal tissue specimens obtained from BE patients.

Cernostics’ CEO, Mike Hoerres, says, "Our TissueCypher Barrett’s Esophagus Assay was developed as a Laboratory Developed Test for the US market and can be developed as an In Vitro Diagnostic for ex-U.S. markets to assess progression of Barrett’s to esophageal cancer. This technology may help clinicians determine personalized care pathways – establishing which BE patients will likely benefit from endoscopic eradication therapies and what are optimal surveillance intervals for future endoscopies."

About Barrett’s

BE affects more than three million Americans, occurring when chronic exposure to stomach acid causes the esophageal cell lining to deteriorate and undergo changes that can create an environment for cancer. Without treatment, Barrett’s can lead to EAC, with a poor 5-year survival of less than 20%[1]. Today, Barrett’s is commonly managed by surveillance, involving regular endoscopic procedures with biopsy, monitoring disease progression, and GERD-related drug therapy to control symptoms and prevent esophageal injury.

Heron Therapeutics to Present at the Evercore ISI HealthCONx Conference

On November 20, 2018 Heron Therapeutics, Inc. (NASDAQ: HRTX), a commercial-stage biotechnology company focused on improving the lives of patients by developing best-in-class treatments to address some of the most important unmet patient needs, reported that Barry D. Quart, Pharm.D., Chief Executive Officer of Heron Therapeutics, will participate in a fireside chat at the Evercore ISI HealthCONx Conference on Tuesday, November 27, 2018, at 10:15 a.m. EST at the Boston Harbor Hotel (Press release, Heron Therapeutics, NOV 20, 2018, https://herontherapeutics.gcs-web.com/news-releases/news-release-details/heron-therapeutics-present-evercore-isi-healthconx-conference [SID1234531522]).

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A live webcast of the event will be available on the Company’s website at www.herontx.com in the Investor Resources section. A replay of the event will be archived on the site for 60 days.