The Medicines Company to Host Conference Call and Webcast Discussing Fourth-Quarter and Full-Year 2017 Financial Results

On February 14, 2018 The Medicines Company (NASDAQ: MDCO) reported that it will host a conference call and webcast on Wednesday, February 21, 2018, at 8:30 a.m., Eastern Time, to discuss fourth-quarter and full-year 2017 financial results and operational developments (Press release, Medicines Company, FEB 14, 2018, View Source;p=RssLanding&cat=news&id=2332543 [SID1234524016]).

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The conference call may be accessed by telephone as follows:

U.S./Canada: (877) 359-9508
International: (224) 357-2393
Conference ID: 3592738
A taped replay of the conference call will be available after the call concludes, and may be accessed by telephone as follows:

U.S./Canada: (855) 859-2056
International: (404) 537-3406
Conference ID: 3592738
A live audio webcast of the conference call may be accessed in the Investors section of The Medicines Company website. An archived webcast will be available after the call concludes.

DelMar Pharmaceuticals Announces Second Quarter

Fiscal Year 2018 Financial Results

On February 14, 2018 DelMar Pharmaceuticals, Inc. (NASDAQ: DMPI) ("DelMar" or the "Company"), a biopharmaceutical company focused on the development of new cancer therapies, reported its financial results for the second quarter ended December 31, 2017 (Press release, DelMar Pharmaceuticals, FEB 14, 2018, View Source [SID1234523988]). DelMar executive management will host a business update conference call for investors, analysts and other interested parties on Tuesday, February 20, 2018 at 4:30 p.m. Eastern Standard Time.

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"This quarter has been an exciting period for DelMar. Our priority is to leverage VAL-083’s unique mechanism of action to efficiently advance it into the most promising indications, including MGMT-unmethylated glioblastoma and platinum-resistant ovarian cancer. We now have a revised VAL-083 development strategy that is focused on MGMT methylation status in glioblastoma, which has become routine in clinical practice as a biomarker which correlates with resistance to the standard-of-care chemotherapy with temozolomide (Temodar "TMZ"), and patient outcomes. We believe using this biomarker will allow us to optimize patient selection for treatment with our lead drug candidate, VAL-083, thereby streamlining development and enhancing opportunities for success in our clinical development programs," commented Saiid Zarrabian, Interim President and Chief Executive Officer.

KEY DEVELOPMENTS AND UPDATED STRATEGIC PLAN

● Evaluation of MGMT promoter methylation status has increasingly become common practice in the diagnostic assessment of glioblastoma multiforme (GBM). DelMar believes that this provides it with an enhanced ability to leverage MGMT methylation as a biomarker to optimize patient selection for DelMar’s novel DNA-targeting agent in the treatment of GBM.

● The National Comprehensive Cancer Network (NCCN), provided updated guidelines for the standard treatment of GBM based on MGMT methylation status. DelMar believes these recently published guidelines may allow the Company to capitalize on VAL-083’s unique mechanism of action and activity in the estimated 60 percent of GBM patients whose tumors are MGMT-unmethylated.

● The U.S. Food and Drug Administration (FDA) allowed a second Investigational New Drug Application (IND) to enable DelMar to study its lead drug candidate, VAL-083, as a potential treatment for ovarian cancer.

● In November 2017, at the annual meeting of the Society for NeuroOncology (SNO), DelMar presented a positive interim update from its ongoing open label Phase 2 clinical trial in patients with MGMT-unmethylated recurrent GBM (rGBM) whose tumors have recurred following treatment with temozolomide (Avastin naïve). This study, which was initiated in February 2017, is being conducted at the University of Texas MD Anderson Cancer Center.

● In December 2017, the FDA fully approved Avastin (bevacizumab) which may impact our ability to recruit suitable patients for our STAR-3 Phase 3 clinical trial.

● In December 2017, the FDA granted Fast Track designation for VAL-083, in recurrent glioblastoma.

● Based on the above developments, and other factors as stated in DelMar’s Quarterly Report on Form 10-Q for the quarter ended December 31, 2017 (10-Q) filed with the Securities and Exchange Commission (SEC) on February 14, 2018, DelMar has decided to put the STAR-3 program on hold for up to 12 months and will suspend further site or patient enrollment. This will allow DelMar to fully evaluate the possible impact of Avastin’s recent approval by the FDA on patient enrollment for this study, and possible protocol amendments, non-dilutive financing sources, as well as to increase focus on the MGMT-unmethylated clinical studies currently underway as further described in the SEC filings. During this interim evaluation period, DelMar will continue to provide treatment to patients already enrolled in the STAR-3 trial, and consider, on a case-by-case basis, and subject to required institutional and regulatory approvals, providing VAL-083 to patients in accordance with our expanded access policy

● Based on this updated strategy, DelMar believes it has cash available into the second quarter of calendar 2019.

For further details on the Company’s operating and financial results, as well as more detail about its updated strategy, refer to DelMar’s 10-Q filed with the SEC on February 14, 2018, View Source

CONFERENCE CALL DETAILS

DelMar plans to host a conference call to discuss its financial results for the quarter ended December 31, 2017 and provide a corporate update on Tuesday, February 20, 2018, at 4:30 p.m. Eastern Time. For both "listen-only" participants and those who wish to take part in the question and answer portion of the call, the telephone Dial-in Number is 1 888 632 3384 (toll free) with Conference ID DELMAR.

A replay of the conference call will be available on the IR Calendar of the Investors section of the Company’s website at www.delmarpharma.com and will be archived for 30 days.

SUMMARY OF FINANCIAL RESULTS FOR THE PERIOD ENDED DECEMBER 31, 2017

At December 31, 2017, the Company had cash and clinical trial deposits on hand of approximately $12.0 million (unaudited).

For the three months ended December 31, 2017, the Company reported a net loss of $3,161,598 or $0.14 per share, compared to a net loss of $1,321,973, or $0.13 per share, for the three months ended December 31, 2016. For the six months ended December 31, 2017, the Company reported a net loss of $5,828,004 or $0.31 per share, compared to a net loss of $3,612,312, or $0.36 per share, for the six months ended December 31, 2016.

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The following represents selected financial information as of December 31, 2017. The Company’s financial information has been prepared in accordance with U.S. GAAP and this selected information should be read in conjunction with DelMar’s consolidated financial statements and management’s discussion and analysis ("MD&A"), as filed.

DelMar’s financial statements as filed with the U.S. Securities Exchange Commission can be viewed on the company’s website at: View Source

Selected Balance Sheet Data


December 31,
2017
$


June 30,
2017
$


Cash 11,021,568 6,586,014
Working capital 9,959,948 6,566,371
Total assets 12,216,116 7,911,021
Derivative liability 5,549 61,228
Total stockholders’ equity 9,983,574 6,578,524

Selected Statement of Operations Data

For the three months ended:

December 31, December 31,
2017 2016
$ $

Research and development 2,141,945 1,120,910
General and administrative 1,011,879 571,286
Change in fair value of stock option and derivative liabilities 889 (361,668 )
Foreign exchange loss (gain) 7,120 (8,495 )
Interest income (235 ) (60 )
Net and comprehensive loss for the period 3,161,598 1,321,973
Series B Preferred stock dividend 54,066 159,756
Net and comprehensive loss available to common stockholders 3,215,664 1,481,729
Basic weighted average number of shares outstanding 22,559,234 11,424,485
Basic and fully diluted loss per share 0.14 0.13

Excluding the impact of non-cash expense, research and development expenses increased to $2,015,570 during the current quarter compared to $1,186,637 for the same period in the prior year. The increase was largely attributable to an increase in clinical development costs related to the three clinical studies ongoing for VAL-083, as well as personnel, and preclinical research costs. Excluding the impact of non-cash expenses, general and administrative expenses increased in the quarter ended December 31, 2017 to $909,747 from $580,761 for the quarter ended December 31, 2016.

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For the six months ended:

December 31, December 31,
2017 2016
$ $

Research and development 4,076,588 1,853,639
General and administrative 1,756,500 1,887,925
Change in fair value of stock option and derivative liabilities (55,679 ) (135,980 )
Foreign exchange loss 50,986 6,829
Interest income (391 ) (101 )
Net and comprehensive loss for the period 5,828,004 3,612,312
Series B Preferred stock dividend 95,732 467,054
Net and comprehensive loss available to common stockholders 5,923,736 4,079,366
Basic weighted average number of shares outstanding 18,882,259 11,363,237
Basic and fully diluted loss per share 0.31 0.36

Excluding the impact of non-cash expense, research and development expenses increased to $3,955,187 during the six months ended December 31, 2017 compared to $1,863,529 for the same period in the prior year. The increase was largely attributable to VAL-083 clinical development and manufacturing costs related to the Company’s STAR-3 refractory-GBM clinical trial and two Phase 2 clinical trials in MGMT-unmethylated GBM.

Excluding the impact of non-cash expenses, general and administrative expenses increased in the current six months to $1,586,005 compared to $1,307,175 for the six months ended December 31, 2016.

We believe, based on our current estimates, that we will be able to fund our operations into the second quarter of calendar year 2019.

Radius Health to Announce Fourth Quarter and Full Year 2017 Financial Results, Host Conference Call and Live Webcast on March 1, 2018

On February 14, 2018 Radius Health, Inc. (Nasdaq:RDUS) reported that it will release its fourth quarter and full year 2017 financial results on Thursday, March 1, 2018 (Press release, Radius, FEB 14, 2018, View Source [SID1234523981]). The Company will host a conference call and live audio webcast at 4:30 p.m. ET that day to discuss the results and provide a company update.

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Conference Call Information
Date: Thursday, March 1, 2018
Time: 4:30 p.m. ET
Domestic Dial-in Number: (866) 323-7965
International Dial-in Number: (346) 406-0961
Conference ID: 3484256
Live webcast: View Source

A replay of the conference call/webcast will be available from March 1, 2018 at 7:30 p.m. ET until March 8, 2018 at 7:30 p.m. ET. To access the replay, dial (855) 859-2056 for U.S. or (404) 537-3406 for International. The replay conference ID is 3484256.

The live audio webcast of the call can be accessed from the Investors section of the Company’s website, www.radiuspharm.com, and a webcast replay will also be available for 14 days. The full text of the announcement and financial results will also be available on the Company’s website.

Radius Health to Present at 2018 RBC Capital Markets Global Healthcare Conference

On February 14, 2018 Radius Health, Inc. (Nasdaq:RDUS) reported that Jesper Høiland, President and CEO of the Company, will present a corporate update at the 2018 RBC Capital Markets Global Healthcare Conference on Thursday, February 22, 2018 (Press release, Radius, FEB 14, 2018, View Source [SID1234523980]).

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Information on the presentation is as follows:

Event: RBC Capital Markets Global Healthcare Conference
Date: Thursday, February 22, 2018
Time: 8:30 a.m. EDT
Location: Lotte New York Palace Hotel, New York, NY
A live webcast of the presentation will be available by visiting the Investors section of Radius’ website at View Source A replay of the webcast will be archived on Radius’ website for 30 days following the presentation.

PDL BioPharma to Present at Two Upcoming Investor Conferences

On February 14, 2018 PDL BioPharma, Inc. (PDL) (NASDAQ: PDLI) reported that John P. McLaughlin, PDL’s chief executive officer, will present at the following two upcoming investor conferences (Press release, PDL BioPharma, FEB 14, 2018, View Source [SID1234523978]):

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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2018 RBC Capital Markets Global Healthcare Conference
Wednesday February 21, 2018 at 9:30 a.m. EST
New York City

Cowen and Company 38th Annual Health Care Conference
Tuesday, March 13, 2018 at 12:00 p.m. EDT
Boston, Massachusetts

To access the live and subsequently archived webcast of these presentations, go to the company’s website at View Source and go to "Presentations and Events." Please connect to the website at least 15 minutes prior to the presentations to allow for any software download that may be necessary. The archived webcasts will be available for at least seven days following the presentations.