BiocurePharm, Korea (“BPK”) Announces Private Placement

On January 21, 2019 Biocure Technology Corp. ("CURE" or the "Company") (CSE:CURE; OTCQB: BICTF) BiocurePharm, Korea ("BPK"), a wholly owned subsidiary of Biocure Technology Inc. ("CURE") reported that it has arranged a non- brokered private placement through its Korean Subsidiary BiocurePharm, Korea ("BPK"), BPK will be issuing up to 100,000 shares at 11,40 CAD per share for gross proceeds of $1.14 Million or more, depending on investor interest (Press release, Biocure Technology, JAN 21, 2019, View Source [SID1234628758]). Finder’s fees or commissions may be payable by the Company in connection with this Private Placement.

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The net proceeds from the non-brokered private placement are intended to be used for general working capital and research and development.

RadioMedix received $2 M SBIR Phase II Contract award from NCI NIH for the targeted alpha-emitter therapy of neuroendocrine cancers

On January 21, 2019 RadioMedix Inc. is reported that the company has been awarded a two-year, $2.0 M Phase II SBIR contract award by the NIH NCI (HHSN261201800048C; UPIID:75N91018C00048) for the clinical development of Targeted Alpha-emitter Therapy (TAT) of neuroendocrine tumors (Press release, RadioMedix, JAN 21, 2019, View Source [SID1234532801]). This Phase II Contract award is a continuation of the successfully completed Phase I SBIR contract (HHSN261201600015C). This award will support the Phase I, non-randomized, open-label, dose escalation study to determine the safety, bio-distribution, and preliminary effectiveness of 212Pb-octreotate analog (AlphaMedix) in adult subjects with Somatostatin Receptor (SSTR) expressing neuroendocrine tumors (NCT03466216). Dr. Izabela Tworowska (RadioMedix) serves as a Principal Investigator of the SBIR Phase II contract and is working together with Dr. Julien Torgue (co-I, Orano Med). The clinical studies are currently on-going at the Excel Diagnostics and Nuclear Oncology Center (Houston, TX).

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"Patients with advanced Neuroendocrine Tumors (NETs) have limited treatment options available to them. Our goal is to address this unmet clinical need by using targeted alpha-emitter therapy", said Izabela Tworowska, PhD, CSO of RadioMedix. "We are grateful to NCI for acknowledging the importance of alpha-emitter therapy and supporting our clinical studies of 212Pb-octreotate analog. This SBIR Phase II Contract is the second award highlighting RadioMedix – Orano Med collaboration."

"TAT is believed to be the next generation of radiopharmaceuticals in the field of Radioligand Therapy (RLT) in oncology. Our proprietary 212Pb labeled agent has potential to advance the effectiveness of Peptide Receptor Radionuclide therapy (PRRT) as compared to currently approved PRRT agents for neuroendocrine cancers", said Dr. Ebrahim S. Delpassand, CEO of RadioMedix. "Unique properties of 212Pb can induce targeted and irreversible damage to the cancer cells, which can result in significant clinical benefits to NET patients", added Dr. Delpassand.

This project has been funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN261201800048C.

Lilly Confirms Date and Conference Call for Fourth-Quarter 2018 Financial Results Announcement

On January 21, 2019 Eli Lilly and Company (NYSE: LLY) reported that it will announce its fourth-quarter and full-year 2018 financial results on Wednesday, February 13, 2019 (Press release, Eli Lilly, JAN 21, 2019, View Source [SID1234532800]). Lilly will also conduct a conference call on that day with the investment community and media to further detail the company’s financial performance.

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The conference call will begin at 9 a.m. Eastern time. Investors, media and the general public can access a live webcast of the conference call through a link that will be posted on Lilly’s website at View Source A replay will also be available on the website following the conference call.

AIVITA Biomedical to Present at Upcoming January Healthcare Conferences

On January 21, 2019 AIVITA Biomedical, Inc., a biotech company specializing in innovative stem cell applications, reported the company will be presenting at two upcoming healthcare conferences. AIVITA’s Chief Medical Officer Dr. Robert O. Dillman will be presenting at Precision Medicine World Conference on Tuesday, Jan. 22, in Santa Clara, California. AIVITA Chairman and Chief Executive Officer Dr. Hans S. Keirstead will speak at Phacilitate Leaders World on Wednesday, Jan. 23, in Miami, Florida.

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Precision Medicine World Conference in Silicon Valley is a healthcare conference for that provides attendees with an opportunity to learn about the latest developments and advancements in precision medicine. Dr. Dillman will be presenting details on AIVITA’s autologous cancer vaccine technology on Tuesday, Jan. 22, at 2:45 p.m. in a talk titled Patient-Specific Cancer Vaccines. He will share past and current clinical data in a presentation focused on antigens from autologous tumor initiating cells.

Co-located with the World Stem Cell Summit, Phacilitate Leaders World is an advanced therapies partnering event that provides attendees with a platform to build new partnerships and discuss cutting-edge therapies. On Wednesday, Jan. 23, at 2:35 p.m. Dr. Keirstead will deliver a talk titled Targeting the Cancer Stem Cell: Clinical Data and Mechanism of Action.

About ROOT OF CANCER

AIVITA’s treatment is a platform technology applicable to most solid tumor types and consists of autologous dendritic cells loaded with autologous tumor antigens from autologous self-renewing tumor-initiating cells.

AIVITA’s ovarian Phase 2 double-blind study is active and enrolling approximately 99 patients who will be randomized in a 2:1 ratio to receive either the autologous dendritic cell vaccine or autologous monocytes as a comparator.

Patients eligible for randomization and treatment will be those (1) who have undergone debulking surgery, (2) for whom a cell line has been established, (3) who have undergone leukapheresis from which sufficient monocytes were obtained, (4) have an ECOG performance grade of 0 or 1 (Karnofsky score of 70-100%), and (5) who have completed primary therapy.

For additional information about AIVITA’s AVOVA-1 trial patients can visit: www.clinicaltrials.gov/ct2/show/NCT02033616

AIVITA’s glioblastoma Phase 2 single-arm study is active and will enroll approximately 55 patients to receive the treatment candidate.

Patients eligible for treatment will be those (1) who have recovered from surgery such that they are about to begin concurrent chemotherapy and radiation therapy (CT/RT), (2) for whom an autologous tumor cell line has been established, (3) have a Karnofsky Performance Status of > 70 and (4) have undergone successful leukapheresis from which peripheral blood mononuclear cells (PBMC) were obtained that can be used to generate dendritic cells (DC).

ACHILLES THERAPEUTICS RECEIVES CTA APPROVAL FOR PHASE I/II STUDY IN NON-SMALL CELL LUNG CANCER – Ground-breaking clinical trial in patients with significant unmet medical need to start this year

On January 21, 2019 Achilles Therapeutics ("Achilles"), a biopharmaceutical company developing personalised cancer immunotherapies, reported that its Clinical Trial Application (CTA) to conduct a Phase I/II study with its lead product, a tumour-derived T cell therapy targeting clonal neoantigens, in development for the treatment of advanced Non-Small Cell Lung Cancer (NSCLC), has been approved by the UK regulatory authority, the Medicines and Healthcare products Regulatory Agency (MHRA) (Press release, Achilles Therapeutics, JAN 21, 2019, View Source [SID1234532798]). The study, an open-label, multi-centre Phase I/II trial evaluating the safety and clinical activity of clonal neoantigen T cells (cNeT) in patients with advanced NSCLC, is expected to enrol the first patient in 2H 2019.

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"Approval of our first CTA represents an important validation of our approach and a significant milestone for Achilles," said Dr Iraj Ali, CEO of Achilles Therapeutics. "Achilles was founded by world-leading experts in cancer evolution, bioinformatics and the delivery of cell-based immunotherapies and we are bringing together these disciplines to develop next-generation, patient-specific T cell therapies that harness the immune system to destroy cancer cells."

"The Achilles approach is a technological step forward in the immune-oncology space with the potential to bring the next wave of revolutionary new immunotherapies to cancer patients," said Dr Martin Forster, Chief Investigator for the study at University College London Hospitals (UCLH), the lead clinical site. "We are excited to be part of the study and look forward to enrolling patients into the clinical trial."

Achilles is developing personalised T cell therapies for solid tumours targeting clonal neoantigens: protein markers unique to each patient that are present on the surface of a cancer cell. Using its PELEUS bioinformatics platform, Achilles can identify clonal neoantigens from each patient’s unique tumour profile which are present on every cancer cell and can be recognised by the immune system. Achilles uses its proprietary process to manufacture clonal neoantigen T cells (cNeT) which exquisitely target the specific set of clonal neoantigens in each patient. The starting material for cNeT are tumour infiltrating lymphocytes (TILs) which are isolated from the patient’s own tumour sample. These T cells are already programmed to invade and attack the tumour, and previous clinical studies have shown that expanded TILs can debulk solid tumours with durable and potent responses. Targeting multiple clonal neoantigens that are present on all cancer cells, but not on healthy cells, reduces the risk that new mutations can induce immune evasion and therapeutic resistance, and allows individualised treatments to target and destroy tumours without harming healthy tissue.

A second clinical study in patients with metastatic or recurrent melanoma is anticipated to open later in 2019.

– Ends –

Further information:

Achilles Therapeutics
Dr Iraj Ali – Chief Executive Officer
+44 (0)1438 906 906
[email protected]

Julia Wilson – Head of Communications
+44 (0)7818 430877
[email protected]

Consilium Strategic Communications
Mary-Jane Elliott, Sukaina Virji, Melissa Gardiner
Tel: +44 (0) 203 709 5000
Email: [email protected]