On June 15, 2023 OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnemo: OSE) reported scientific updates in oral and poster presentations selected for international conferences: at the Antibody Engineering & Therapeutics Europe 2023 Conference in Amsterdam, Netherlands (June 7), at the FOCIS 2023 Annual Meeting (June 20-23), the 4th Annual Cytokine-Based Drug Development Summit 2023 (June 27-29) and at the 3rd Annual Tumor Myeloid-directed Therapies Summit 2023 (July 18-20) in Boston, US (Press release, OSE Immunotherapeutics, JUN 15, 2023, View Source [SID1234632769]). The communications feature the latest research on pre-IND programs for BiCKI-IL-7 (bifunctional therapy targeting PD-1 and IL-7), CLEC-1(1) (new myeloid immune checkpoint) in immuno-oncology and for OSE-230 (first pro-resolutive monoclonal antibody) in chronic inflammation.

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Dr Nicolas Poirier, Chief Executive Officer of OSE Immunotherapeutics, commented: "We are very proud to share our latest scientific advances on our innovative pre-IND research programs with the international scientific community. The progress made on our next-generation immunotherapies in immuno-oncology and immuno-inflammation demonstrate our continued commitment to delivering first-in-class treatments for patients in high need for new therapeutic options. We are looking forward to progressing these programs with strategic partners into clinical stage".

Dr Aurore Morello, Head of Research of OSE Immunotherapeutics, said: "The latest data featured in our communications highlight the value and therapeutic potential of our pre-IND assets.

BiCKI-IL-7, our bispecific anti-PD1/IL-7 program, presents an innovative cytokine approach, selectively targeting tumor-specific T-cells to improve the quality and durability of memory T-lymphocyte responses.

CLEC-1, developed in academic collaboration with Dr Elise Chiffoleau’s team at the Center for Translational Research in Transplantation and Immunology (1) in Nantes, acts as a new myeloid immune checkpoint and the CLEC-1/new ligand TRIM21 axis as a new target for cancer immunotherapy. These latest data further support the preclinical evaluation of monoclonal antagonist antibodies targeting CLEC-1.

OSE-230, our most advanced pre-IND program, stands as the first pro-resolutive agonist monoclonal antibody, capable of clearing chronic neutrophil infiltrates and inhibiting the pathogenic NETosis (2) process and fibrosis".

BICKI-IL-7 PROGRAM IN IMMUNO-ONCOLOGY

ANTIBODY ENGINEERING & THERAPEUTICS EUROPE 2023 – JUNE 7, AMSTERDAM
Presenter: Aurore Morello, PhD., Head of Research of OSE Immunotherapeutics

"Anti-PD1/IL7v Cis-activated Stem-like T cells Expressing TCF1"
Human tumor-specific T cells expressed PD1. Stem-like TCF1+ T cells are key for the efficient and durable response of anti-PD1 mAbs in clinic (3). Stem-like TCF1+ co-express PD1 and CD127 and an anti-PD1/IL7v bifunctional molecule preferentially cis-target and expand the proliferation and survival of stem-like TCF1+ T cells without inducing their exhaustion in vitro in human chronic stimulation and exhaustion assays as well as in-vivo in tumor bearing mice.

4TH ANNUAL CYTOKINE-BASED DRUG DEVELOPMENT SUMMIT 2023 – JUNE 27-29, BOSTON
Day: Pre-Conference Workshop Day
Time: 9:00 am
Presenter: Nicolas Poirier, PhD, CEO and CSO of OSE Immunotherapeutics
Seminar:

"Going Beyond IL-2 to Explore Different Possibilities for the Development of Cytokine-Based Drugs"
Although the IL-2s have been the forefront of research within the field of cytokine-based drugs, many interleukins and interferons beyond IL-2 are becoming increasingly relevant. The applications of these cytokines are vast and their different mechanisms of action open up the field to more R&D and an endless number of possibilities to tackle the various diseases affecting the world.

Join this workshop to:

Discuss the progress of novel technologies on IL-7, IL-12, IL-18, IL-15 and more.
Understand the different mechanisms and mode of action employed by these cytokines.
Explore the TNF super family and interferons.
Understand clinical evaluation of non-alpha IL-2 and IL-15 cytokine therapies and implications for future drug development.
Discover how anti-PD1/IL7v bispecific selectively expand and maintain stemness of TCF1+ stem-like T cells.
CLEC-1 PROGRAM IN IMMUNO-ONCOLOGY

3RD ANNUAL TUMOR MYELOID-DIRECTED THERAPIES SUMMIT 2023 – 18-20 JULY, BOSTON
Day: Day Two
Time: 9:30 am
Presenter: Nicolas Poirier, PhD, CEO and CSO of OSE Immunotherapeutics

"CLEC-1 is a Novel Inhibitory Myeloid Receptor Sensing Cell Death & Limiting Tumor Antigen Cross-Presentation"

Details:

The orphan receptor CLEC-1 interacts with Trim21 over-expressed during cell death.
CLEC-1 inhibitory function limits T-cell cross-priming.
Positive preclinical efficacy with antagonist anti-CLEC1 mAb.
OSE-230 PROGRAM IN INFLAMMATION DISEASE

FOCIS 2023 ANNUAL MEETING – 20-23 JUNE, BOSTON
Date: June 20
Presenter: Vanessa Gauttier, Researcher, OSE Immunotherapeutics

Tu 220 – "Agonist anti-ChemR23 mAb inhibits NETosis and neutrophil-mediated inflammation"

(1) Collaborative academic program between OSE Immunotherapeutics and Dr Elise Chiffoleau’s research teams (Center for Research in Transplantation and Translational Immunology (CR2TI), UMR1064, INSERM, Nantes University at Nantes University Hospital, View Source).

(2) NETosis is a program for formation of neutrophil extracellular traps (NETs), which consists of modified chromatin decorated with bactericidal proteins from granules and cytoplasm. Recent research has highlighted that neutrophils, and in particular NETs that can be released upon activation, have central roles in the initiation and perpetuation of systemic autoimmune disorders and trigger complex and chronic inflammatory responses that lead to organ damage and fibrosis.

(3) Connolly K A et al. Sci Immunol. 2021, A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response