On February 1, 2023 Orbit Discovery Limited (Orbit), a leader in the discovery of therapeutic peptide hits, reported it has entered into a multi target Research Agreement with Endevica Bio Inc., (Endevica), a company dedicated to creating first-in-class therapeutics for cachexia caused by cancer and other chronic conditions, with its lead compound having proven safe and well-tolerated in its Phase 1 trials (Press release, Orbit Discovery, FEB 1, 2023, View Source [SID1234626748]). The collaboration aims to accelerate Endevica’s development of advanced G-protein coupled receptor (GPCR)-targeting therapeutics on receptor sets both novel and complimentary to its lead compound.
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Endevica’s technology platform allows for the modification of peptides to modulate activity of GPCRs behind the blood-brain barrier. The focus of this agreement is to identify peptide hits from selected library populations, derived from Endevica’s internal in silico and modelling tools, which will be applied directly to Orbit’s proprietary functional screening platform where agonism of proteins can be identified. The platform allows for millions of independent peptide sequences to be screened using a combination of bead-based DNA encoded libraries and microfluidic droplet screening. The peptide display engine is uniquely able to address soluble targets and targets in situ, both on and in cells, allowing for significantly faster discovery times of relevant peptide leads based on affinity screens and/or functional screens.
The agreement covers activities ranging from hit ID to development of cell-based assays, with an option for Endevica to further develop the peptide hits resulting from the screening activities.