Onconova Therapeutics, Inc. to Present New Data on Briciclib and Next-Generation CDK4/6 Inhibitor, ON 123300, at 2015 AACR-NCI-EORTC Meeting

On October 29, 2015 Onconova Therapeutics, Inc. (NASDAQ:ONTX), a clinical-stage biopharmaceutical company focused on discovering and developing novel products to treat cancer, reported the presentation of new non-clinical data for two of the Company’s proprietary compounds at the 2015 AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper), which will be held November 5-9, 2015, in Boston, MA (Press release, Onconova, OCT 29, 2015, View Source [SID:1234507843]).

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A poster relating to the novel eIF4E targeted mechanism of action for briciclib, currently in a dose-escalating Phase 1 clinical trial in patients with advanced solid tumors refractory to current therapies, will be presented by Onconova’s collaborators from Harvard University. Another poster will highlight the developmental studies aimed at advancing the Company’s novel CDK4/6 inhibitor, ON 123300, towards an Investigational New Drug (IND) Application filing. The presentations are listed below.

Mechanism of action studies for briciclib

Abstract number: B126
Title: Targeted inhibition of eIF4E-mediated translation by the novel small molecule anti-cancer compound, briciclib (ON 013105).
Date: Saturday, 11/7/2015
Time: 12:30 PM — 3:30 PM ET
Location: Session B, Hall C-D

IND-directed studies for next-generation CDK4/6 inhibitor ON 123300

Abstract number: LB-A21
Title: Single-agent activity and favorable pharmaceutical properties of orally bioavailable next-generation CDK4/6 inhibitor, ON 123300.
Date: Friday, 11/6/2015
Time: 12:15 PM — 3:15 PM ET
Location: Session A, Hall C-D