On October 27, 2015 OncoMed Pharmaceuticals Inc. (NASDAQ:OMED) reported that data related to three of its clinical-stage programs will be presented at the upcoming AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper) taking place November 5-9, 2015 in Boston, MA (Press release, OncoMed, OCT 27, 2015, View Source [SID:1234507805]).
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Among the abstracts accepted for presentation are Phase 1a data for single-agent brontictuzumab (anti-Notch1, OMP-52M51) in advanced solid tumors, including initial results from an expansion cohort of patients whose tumors demonstrate an overexpression of the activated form of Notch1 as measured by a companion biomarker. In addition, biomarker data for vantictumab (anti-Fzd7, OMP-18R5) in non-small cell lung cancer, as well as results of preclinical studies for OncoMed’s anti-DLL4/VEGF bispecific (OMP-305B83), will also be presented. Details for the presentation are provided below.
Friday, November 6, 2015
Abstract #A30: Predictive and pharmacodynamic biomarkers of vantictumab (OMP-18R5; anti-Frizzled) in non-small cell lung cancer
Lead author: Ann Kapoun, Ph.D., OncoMed
Poster session A: Biomarkers
Time and location: 12:15 pm – 3:15 pm / Exhibit hall C-D
Sunday, November 8, 2015
Abstract #C42: Safety and preliminary efficacy results of a first-in-human Phase I study of the novel cancer stem cell (CSC) targeting antibody brontictuzumab (OMP-52M51, anti-Notch1) administered intravenously to patients with certain advanced solid tumors
Lead author: Pamela Munster, M.D., University of California, San Francisco
Poster session C: Clinical Trials
Location and time: 12:30 pm – 3:30 pm / Exhibit hall C-D
Abstract #C164: Dual targeting of the DLL4 and VEGF pathways with a bispecific monoclonal antibody inhibits tumor growth and reduces cancer stem cell frequency
Lead author: Wang-Ching Yen, Ph.D., OncoMed
Poster session C: Therapeutic Agents: Biological
Time and location: 12:30 pm -3:30 pm / Exhibit hall C-D