On October 3, 2023 OncoHost, a technology company transforming the approach to precision medicine for improved patient outcomes, reported a collaboration with Hengenix Biotech, Inc. (Henlius USA), affiliated with Shanghai Henlius Biotech, Inc., a global biopharmaceutical company with the vision to offer high-quality, affordable, and innovative biologic medicines for patients worldwide with a focus on oncology, autoimmune diseases, and ophthalmic diseases. Henlius USA will utilize OncoHost’s PROphet platform to identify exploratory, correlative biomarkers for patients recruited in its comprehensive Phase III clinical trial (NCT05468489). The trial is evaluating the efficacy and safety of Serplulimab plus chemotherapy (carboplatin – etoposide) in previously untreated US-based patients with Extensive-Stage Small Cell Lung Cancer (ES-SCLC).
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OncoHost’s PROphet platform combines bioinformatics, system biology, proteomic pattern recognition and machine learning to predict clinical benefit probability (defined as prolonged progression-free survival) in response to immunotherapy. PROphet analyzes 7,000 proteins in patient blood samples using aptamer-based assays (SomaScan by Somalogic (NASDAQ: SLGC)) and combines data collection with machine learning models for patient selection, OS (overall survival)/PFS (progression-free survival) prediction, MoA (Mechanisms of Action) discovery, AE (adverse events) prediction, and response prediction. The platform is applicable in oncology, autoimmune diseases, inflammation, and inflammatory bowel disease.
PROphet has been added to the comprehensive Phase III clinical trial to evaluate the efficacy of Serplulimab combined with chemotherapy in comparison to the standard-of-care atezolizumab combined with chemotherapy, identifying potential proteomics-based biomarkers to better characterize possible resistance patterns in recruited patients. The goal of this collaboration is to add another layer of information to the study by offering insight into who will benefit from the targeted combination therapy.
"We stand at the height of a transformative era in cancer therapeutics, and we are honored to support Henlius USA in better understanding resistance mechanisms to truly personalize care," said Ofer Sharon, MD, CEO of OncoHost. "Our shared goal is to improve cancer patients’ outcomes by developing robust, scientifically sound technologies to support them and their caregivers. We believe that such collaborations hold the potential to bring new hope to those affected by this challenging disease."