On September 10, 2024 OncoHost, a technology company transforming the approach to precision medicine for improved patient outcomes, reported its selection to present a poster at the European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress 2024, which will take place from September 13 to 17, 2024, in Barcelona, Spain (Press release, OncoHost, SEP 10, 2024, View Source [SID1234646481]).
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The abstract, titled "A plasma proteomic based algorithm is associated with prognosis in renal cell carcinoma," highlights the extended application of OncoHost’s PROphet platform beyond non-small cell lung cancer (NSCLC) to renal cell carcinoma (RCC). This research represents a collaboration between OncoHost and Dana-Farber Cancer Institute, a world leader in adult and pediatric cancer treatment and research. The findings will be presented by Dr. Eddy Saad, MD, MSc, a Postdoctoral Research Fellow at Dana-Farber.
"In this work, we demonstrated that OncoHost’s plasma-based proteomic model, initially trained and validated in NSCLC, can also be applied to another tumor type, RCC, to risk stratify patients," said Dr. Eddy Saad, MD, MSc, Postdoctoral Research Fellow at Dana-Farber, and co-author of the abstract. "Moving forward, we aim to further develop and train an RCC-specific model and assess its predictive abilities to guide patient treatment."
The study explored the use of OncoHost’s PROphet platform in a cohort of 201 RCC patients treated with various therapies, including VEGFR tyrosine kinase inhibitors (TKIs), immune checkpoint inhibitors (ICIs), or a combination of both. The results demonstrated that patients identified as PROphet-POSITIVE had significantly improved overall survival (OS) and progression-free survival (PFS) compared to PROphet-NEGATIVE patients, indicating the platform’s potential to predict clinical outcomes across various cancer types.
Furthermore, the research uncovered distinct subsets of circulating proteins associated with clinical benefit among patients treated with different therapies, suggesting that the proteomic features leveraged by the PROphet platform may have broad predictive value. These findings provide a strong foundation for further exploration of PROphet’s application in other cancer indications and treatment contexts.
"This research marks another important milestone for OncoHost, as it demonstrates the versatility and potential of our PROphet platform across different cancer types. By validating the use of our proteomic model in renal cell carcinoma, we are moving closer to our goal of providing personalized treatment plans that significantly improve patient outcomes," said Ofer Sharon, MD, CEO of OncoHost. "We are honored to partner with Dana-Farber in presenting these findings at ESMO (Free ESMO Whitepaper) 2024 and look forward to further expanding the clinical applications of our technology."
Poster Presentation Details
Title: A plasma proteomic based algorithm is associated with prognosis in renal cell carcinoma
Presentation #: 1707P
Title: A plasma-based proteomic platform for predicting clinical benefit from immune checkpoint inhibitors in multiple cancers.
Presenter: Eddy Saad, MD, MSc, Postdoctoral Research Fellow at Dana-Farber Cancer Institute
Date: Sunday, 15 September 2024