Nutcracker Therapeutics to Present Data on mRNA Drug Candidate and Immunomodulatory Cytokine at AACR 2024

On March 12, 2024 Nutcracker Therapeutics, Inc., a biotechnology company dedicated to developing transformative RNA therapies through its proprietary technology platform, reported that two poster presentations highlighting the company’s RNA therapeutics pipeline will be introduced at the 2024 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting (Press release, Nutcracker Therapeutics, MAR 12, 2024, View Source [SID1234641086]).

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The first presentation entails LIGHT, an immunomodulatory cytokine that is one of the components of NTX-250, the company’s lead candidate for cervical intraepithelial neoplasia. The second presentation is on preclinical data for Nutcracker’s mRNA drug candidate for prostate cancer, NTX-470. This therapy is designed to target prostate cancer antigens with mRNA-encoded, multi-specific T cell engagers with a strong anti-tumor effect and low toxicity.

Poster Presentations at AACR (Free AACR Whitepaper) 2024

Title: NTX-470, a novel multispecific T cell engager expressed from mRNA targets PSMA and STEAP1 prostate cancer antigens to generate enhanced functional activity
Abstract Number: 6725
Session Title: Targeted Immune Cell Engagers
Session Date and Time: April 10, 2024, 9:00 a.m. to 12:30 p.m.
Lead Author: Chris Rae

Title: Enhanced membrane stability of mRNA nanoparticle derived TNFSF14 results in superior T- cell and NK cell stimulation
Abstract Number: 6536
Session Title: Tumor Microenvironment and Cancer Immunity
Session Date and Time: April 9, 2024, 1:30 p.m. to 5:00 p.m.
Lead Author: Adrienne Sallets

The 2024 AACR (Free AACR Whitepaper) Annual Meeting takes place in San Diego from April 5-10. Full abstracts are available on the AACR (Free AACR Whitepaper) Online Program Planner. More information about the conference can be found on AACR (Free AACR Whitepaper)’s website.