On May 3, 2022 NiKang Therapeutics Inc. ("NiKang"), a clinical stage biotech company focused on developing innovative small molecule oncology medicines to help patients with unmet medical needs and Hansoh Pharmaceutical Group Company Limited ("Hansoh Pharma", 3692.HK), a China and US based leading biopharmaceutical company, reported an exclusive collaboration and license agreement for the development and commercialization of NKT2152, for the treatment of cancer in Greater China, including Mainland China, Hong Kong, Macau and Taiwan (Press release, NiKang Therapeutics, MAY 3, 2022, View Source [SID1234613425]).
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"Hansoh is a leader in the development and commercialization of small molecules for the treatment of cancer in China. We are thrilled to collaborate with them to strategically advance NKT2152 and expand its reach as a potential treatment for multiple tumor types," said Zhenhai Gao, Ph.D., Co-founder, President and Chief Executive Officer of NiKang. "By combining NiKang’s precision oncology expertise with Hansoh’s proven development and commercialization capabilities in Greater China, we believe that we will be able to accelerate global development of NKT2152 and bring it as a potential novel cancer treatment to China patients sooner."
"We are excited to enter into this agreement and we look forward to working with NiKang, a leader in developing innovative small molecule oncology medicines," said Yuan Sun, Executive Director of the Board of Hansoh Pharma. "HIF2α plays an important role in the development and progression of kidney and other cancers. Based on the sound biology, excellent potency and PK profile observed in preclinical studies, we believe NKT2152 has the potential to become a best-in-class molecule to address this important pathway. Our extensive expertise in oncology drug development can help accelerate development and advance NKT2152 as quickly as possible for cancer patients in China."
Under the terms of the agreement, NiKang will receive an upfront cash payment of $15 million and will be eligible to receive up to $203 million in potential development, regulatory and sales-based milestone payments, and tiered royalties. Hansoh will be responsible for all the development costs for NKT2152 in Greater China and will receive the exclusive rights to develop and commercialize NKT2152 in the region.
About NKT2152
NKT2152 is a small molecule that inhibits HIF2α. It is currently in a phase 1/2 dose escalation and expansion trial (NCT05119335). This trial is designed to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics and clinical activity in patients with advanced ccRCC.