On JUne 4, 2019 Patrick Soon-Shiong, MD, Chairman and CEO of NantKwest (Nasdaq:NK), a leading clinical-stage, natural killer cell based therapeutics company reported a clinical data update in patients who have received off-the-shelf aNK and/or haNK natural killer cell therapy in combination with immunotherapeutic agents in advanced solid tumors (Press release, NantKwest, JUN 4, 2019, https://ir.nantkwest.com/news-releases/news-release-details/nantkwest-announces-durable-complete-responses-multiple-advanced?field_nir_news_date_value[min]=2019 [SID1234536874]). These results demonstrated durable complete responses in 5 out of 35 patients with highly refractory late stage cancers across multiple tumor types.
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Data presented at the Jefferies Healthcare Conference demonstrated complete responses across phase I combination studies of aNK/haNK with or without N-803, ImmunityBio, Inc.’s IL-15 fusion superagonist in solid tumor cancer patients with highly refractory disease. ImmunityBio, Inc. (formerly known as NantCell, Inc.) is an affiliated company of NantKwest. These combinations enhance NK and T cell activity and proliferation, and resulted in 14% complete responses across multiple indications, while demonstrating positive safety profiles. In patients with highly refractory and relapsed diseases who have failed multiple rounds of standard-of-care therapy, the responses were durable.
All five patients with complete responses remain alive to date, ranging from 4 to 24 months from the onset of response.
"We are excited by the durable complete responses seen in patients with highly refractory disease safely treated with off-the-shelf haNK or aNK — to date over 511 infusions of haNK cell therapy have been administered, without any patient requiring hospitalization or resulting in cytokine release syndrome," said Patrick Soon-Shiong, M.D. "These early signals of efficacy have now provided us a pathway to the development of registration trials across triple negative breast cell and Merkel cell carcinoma."
In addition, Dr. Soon-Shiong also announced the FDA authorization of a trial utilizing the first in class CD19 T-haNK for treatment of refractory diffuse large B-Cell Lymphoma and the IND filing of the first in class PD-L1 T-haNK for refractory solid tumors.
For additional information please go to www.nantkwest.com.