On September 27, 2024 Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN), a clinical-stage biotech company developing a new class of custom-built protein drugs known as DARPin therapeutics, reported that the Company will present on its lead-212 (212Pb)-labeled Radio-DARPin Therapeutic (RDT) targeting delta-like ligand 3 (DLL3) co-developed with Orano Med, at the European Assocation of Nuclear Medicine (EANM) Congress which runs October 19-23, 2024 in Hamburg, Germany (Press release, Molecular Partners, SEP 27, 2024, View Source [SID1234646884]).
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The presentation details are as follows:
Title: Preclinical Assessment of Lead-212 (212Pb) Radio-DARPin Therapeutic (RDT)
Targeting Delta-like Ligand 3 (DLL3) in Small Cell Lung Cancer (SCLC)
Presentation Number: OP-535
Session Number: 1204
Session Title: M2M Track – Top Rated Oral Presentation (TROP) Session: Radiopharmaceutical Sciences + Translational Molecular Imaging & Therapy Committee: From Radionuclide to Clinical Translation
Session Timing & Location: October 22, 2024; 8:00-9:30 a.m. CET, Hall X1–X4
Presentation Timing: October 22, 2024; 9:20-9:30 a.m. CET
The presentation will be made available on Molecular Partners’ website after the conference.
Molecular Partners is developing a unique and innovative RDT platform for targeted delivery of radioactive payloads to solid tumors. Due to their small size, high specificity and affinity, DARPins are well-suited as vector for efficient delivery of therapeutic radionuclides. In June 2024, Molecular Partners, together with Targeted Alpha Therapy pioneers Orano Med, announced MP0712, a 212Pb-labeled DLL3-targeting radiopharmaceutical as their first co-developed RDT candidate.
DLL3 is a priority target for radiopharmaceutical therapy thanks to its abundant expression in tumors of patients with SCLC (>85%) and other aggressive neuroendocrine tumors, while expression in healthy tissues is low.
At EANM 2024, Molecular Partners will present their preclinical results supporting MP0712 as a promising treatment candidate for SCLC, with an attractive biodistribution profile, potent antitumor activity and a good safety profile.